Jennifer MartinSenior Instructor
Porter room B257B
Explore Jennifer Martin's areas of research and more in Vivo
Ph.D., University of Washington, 1987
B-cell immortalization by Epstein-Barr virus; signal transduction; tumor virology; malignant transformation.
Viruses are the etiologic agent in 15% of human cancers. Epstein-Barr virus (EBV), a human herpesvirus, is one of 8 identified human tumor viruses and is causally associated with a number of human cancers, including African Burkitt's lymphoma, Hodgkin's Disease, nasopharyngeal carcinoma and B cell lymphomas in immunocompromised individuals (i.e. AIDS patients, transplant recipients). Unique to this virus is its ability immortalize human B cells with great efficiency. EBV infects naive B lymphocytes and converts them from a state of quiescence in which the cells do not divide at all to a state of perpetual cell division in which the cells are immortal. To accomplish this feat, EBV gains entry to the B cell via the complement receptor CR2 and simultaneously activates cellular signaling pathways by activating CR2. This process sets the stage for subsequent viral gene expression and replication. Shortly after infection, several viral genes are expressed, 4 of which are key for initiation and/or maintenance of the immortalized state. These latently infected cells will divide ad infinitum and thus are immortal. The overall goal of the research in my laboratory is aimed at understanding the process of EBV immortalization of B cells at the level of signal transduction, all the while keeping in sight the long-term objective of identifying avenues of therapeutic or preventive intervention.
Epstein-Barr virus latent membrane protein-1 (LMP-1) and lytic LMP-1 localization in plasma membrane-derived extracellular vesicles and intracellular virions.
Vazirabadi, G, Geiger, TR, Coffin, WF3, and Martin, JM J Gen Virol, 84(Pt 8):1997-2008. 2003
Transmembrane domains 1 and 2 of the latent membrane protein 1 of Epstein-Barr virus contain a lipid raft targeting signal and play a critical role in cytostasis.
Coffin, WF3, Geiger, TR, and Martin, JM J Virol, 77(6):3749-58. 2003
The cytoplasmic amino-terminus of the Latent Membrane Protein-1 of Epstein-Barr Virus: relationship between transmembrane orientation and effector functions of the carboxy-terminus and transmembrane domain.
Coffin WF3, Erickson, KD, Hoedt-Miller, M, and Martin, JM Oncogene, 20(38):5313-30. 2001
The late lytic LMP-1 protein of Epstein-Barr virus can negatively regulate LMP-1 signaling.
Erickson, KD and Martin, JM J Virol, 74(2):1057-60. 2000
Early detection of the lytic LMP-1 protein in EBV-infected B-cells suggests its presence in the virion.
Erickson, KD and Martin, JM Virology, 234(1):1-13. 1997