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C elegans pro-1 activity is required for ... ifferentiation in the germ line
C elegans pro-1 activity is required for somagermline interactions that influence proliferation and differentiation in the germ line
5384
Strict spatial and temporal regulation of proliferation and differentiation is essential for proper germline development and often involves soma/germline interactions. In C. elegans, a particularly striking outcome of defective regulation of the proliferation/differentiation pattern is the Pro phenotype in which an ectopic mass of proliferating germ cells occupies the proximal adult germ line, a region normally occupied by gametes. We describe a reduction-of-function mutation in the gene pro-1 that causes a highly penetrant Pro phenotype. The pro-1 mutant Pro phenotype stems from defects in the time and position of the first meiotic entry during early germline development. pro-1(RNAi) produces a loss of somatic gonad structures and concomitant reduction in germline proliferation and gametogenesis. pro-1 encodes a member of a highly conserved subfamily of WD-repeat proteins. pro-1(+) is required in the sheath/spermatheca lineage of the somatic gonad in its role in the proper establishment of the proliferation/differentiation pattern in the germline. Our results provide a handle for further analysis of this soma-to-germline interaction.
Killian DJ, Hubbard EJ
Development (Cambridge, England)
2004-03-01 00:00
131
6
1267-78
Animals,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Cell Differentiation,Cell Division,Contractile Proteins,Genes, Reporter,Germ Cells,Gonads,Meiosis,Membrane Glycoproteins,Microfilament Proteins,Phenotype,Profilins,Recombinant Fusion Proteins,Sequence Deletion,Caenorhabditis elegans Proteins,Contractile Proteins,Glp-1 protein, C elegans,Membrane Glycoproteins,Microfilament Proteins,Profilins,Recombinant Fusion Proteins
Department of Biology New York University, New York, NY 10003, USA.
Development
NIGMS GM61706, NICHD T32HD07520
0950-1991
10.1242/dev.01002
dev.01002
0
False
14973273
