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Chromosome-microtubule interactions during mitosis
Chromosome-microtubule interactions during mitosis
5343
Spindle microtubules interact with mitotic chromosomes, binding to their kinetochores to generate forces that are important for accurate chromosome segregation. Motor enzymes localized both at kinetochores and spindle poles help to form the biologically significant attachments between spindle fibers and their cargo, but microtubule-associated proteins without motor activity contribute to these junctions in important ways. This review examines the molecules necessary for chromosome-microtubule interaction in a range of well-studied organisms, using biological diversity to identify the factors that are essential for organized chromosome movement. We conclude that microtubule dynamics and the proteins that control them are likely to be more important for mitosis than the current enthusiasm for motor enzymes would suggest.
McIntosh JR, Grishchuk EL, West RR
Annual review of cell and developmental biology
2002-01-01 00:00
18
0
193-219
Animals,Centromere,Chromosomes,Eukaryotic Cells,Genes, cdc,Humans,Kinetochores,Microtubules,Mitosis,Mitotic Spindle Apparatus,Molecular Motor Proteins,Molecular Motor Proteins
Department of Molecular Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347, USA. richard.mcintosh@colorado.edu
Annu. Rev. Cell Dev. Biol.
1081-0706
10.1146/annurev.cellbio.18.032002.132412
032002.132412
0
False
12142285
