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Embryonic cortical neural stem cells mig ... s postnatal striatal stem cells
Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells
2229
Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1(IREScre); LacZ/EGFP double-transgenic murine cells from midgestation into adulthood. Lineage tracing in combination with direct cell labeling and time-lapse video microscopy demonstrated that Emx1-lineage embryonic cortical stem cells migrate ventrally into the striatal germinal zone (GZ) perinatally and intermingle with striatal stem cells. Upon integration into the striatal GZ, cortical stem cells down-regulate Emx1 and up-regulate Dlx2, which is a homeobox gene characteristic of the developing striatum and striatal neural stem cells. This demonstrates the existence of a novel dorsal-to-ventral migration of neural stem cells in the perinatal forebrain.
Willaime-Morawek S, Seaberg RM, Batista C, Labbé E, Attisano L, Gorski JA, Jones KR, Kam A, Morshead CM, van der Kooy D
The Journal of cell biology
2006-10-09 00:00
175
1
159-68
Animals,Basal Ganglia,Cell Lineage,Cell Movement,Cerebral Cortex,Embryo,Gene Expression Regulation, Developmental,Genes, Reporter,Green Fluorescent Proteins,Homeodomain Proteins,Mice,Mice, Transgenic,Microscopy, Video,Neurons,Phenotype,Stem Cells,Transcription Factors,Distal-less homeobox proteins,Homeodomain Proteins,Transcription Factors,empty spiracles homeobox proteins,Green Fluorescent Proteins
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. swmorawek@gmail.com
J. Cell Biol.
0021-9525
10.1083/jcb.200604123
jcb.200604123
0
False
17030986
