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Interaction between the transcription fa ... en protein binding zinc fingers
Interaction between the transcription factor SPBP and the positive cofactor RNF4 An interplay between protein binding zinc fingers
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The activator of stromelysin 1 gene transcription, SPBP, interacts with the RING finger protein RNF4. Both proteins are ubiquitously expressed and localized in the nucleus. RNF4 facilitates accumulation of specific SPBP-DNA complexes in vitro and acts as a positive cofactor in SPBP-mediated transactivation. SPBP harbors an internal zinc finger of the PHD/LAP type. This domain can form intra-chain protein-protein contacts in SPBP resulting in negative modulation of SPBP-RNF4 interaction.
Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P
The Journal of biological chemistry
2000-08-25 00:00
275
34
26144-9
3T3 Cells,Amino Acid Sequence,Animals,Cell Nucleus,DNA-Binding Proteins,Escherichia coli,Fibroblasts,Humans,Matrix Metalloproteinase 3,Mice,Molecular Sequence Data,Nuclear Proteins,Peptide Mapping,Protein Binding,Saccharomyces cerevisiae,Trans-Activation (Genetics),Transcription Factors,Transcription, Genetic,Zinc Fingers,DNA-Binding Proteins,Nuclear Proteins,RNF4 protein, human,Rnf4 protein, mouse,TCF20 protein, human,Transcription Factors,Matrix Metalloproteinase 3
Department of Molecular and Structural Biology, University of Aarhus, C. F. Mollers Alle 130, DK-8000 Aarhus C., Denmark.
J. Biol. Chem.
0021-9258
10.1074/jbc.M003405200
M003405200
0
False
10849425
