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Regulation of apoptosis by E1A and Myc oncoproteins
Regulation of apoptosis by E1A and Myc oncoproteins
5394
E1A and c-myc are oncogenes that can deregulate the cell cycle and promote transformation under conditions where normal cell-cycle checkpoints are inactivated. In situations where cell-cycle checkpoints are intact, the E1A and c-Myc proteins potently induce apoptosis, a property that is believed to be the end result of a cellular response to uncontrolled growth-promoting signals. p53 is a key regulator of E1A and c-myc-induced apoptosis and, together with the oncoproteins, may transcriptionally activate numerous genes whose products influence, or are themselves, members of the core apoptotic machinery. The upstream signaling events and the ultimate apoptotic pathways activated by E1A and c-Myc are discussed in this review.
Breckenridge DG, Shore GC
Critical reviews in eukaryotic gene expression
2000-01-01 00:00
10
3
273-80
Adenovirus E1A Proteins,Apoptosis,Humans,Proto-Oncogene Proteins c-myc,Signal Transduction,Tumor Suppressor Protein p53,Adenovirus E1A Proteins,Proto-Oncogene Proteins c-myc,Tumor Suppressor Protein p53
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
Crit. Rev. Eukaryot. Gene Expr.
1045-4403
0
False
11272469
