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Genomic representations using concatenat ... ndonuclease digestion fragments
Genomic representations using concatenates of Type IIB restriction endonuclease digestion fragments
7334
We have developed a method for genomic representation using Type IIB restriction endonucleases. Representation by concatenation of restriction digests, or RECORD, is an approach to sample the fragments generated by cleavage with these enzymes. Here, we show that the RECORD libraries may be used for digital karyotyping and for pathogen identification by computational subtraction.
Tengs T, LaFramboise T, Den RB, Hayes DN, Zhang J, DebRoy S, Gentleman RC, O'Neill K, Birren B, Meyerson M
Nucleic acids research
2004-01-01 00:00
32
15
e121
Bacteria,Computational Biology,Computer Simulation,DNA, Concatenated,Deoxyribonucleases, Type II Site-Specific,Genome, Human,Genomic Library,Genomics,Humans,Karyotyping,Markov Chains,Polymerase Chain Reaction,Viruses,DNA, Concatenated,Deoxyribonucleases, Type II Site-Specific
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Nucleic Acids Res.
NCI 1R01CA098185-01A1, NCI R01 CA098185-02, NIAID T32-AI-07358
1362-4962
10.1093/nar/gnh120
32/15/e121
0
False
15329383
