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From bench to bedside: lecture schedule and reading
MCDB 4201
“From bench to bedside: the role of science in medicine” MCDB 4201
Tuesdays and Thursdays, Room A1B20 12:30-1:45PM
8/25&8/27 L. Leinwand Introduction to the Class/ Development of models for finding cardiac therapeutics
Papers: secor and diamond
Brian L. Stauffer,1,2 John P. Konhilas,2 Elizabeth D. Luczak,2 and Leslie A. Leinwand1,2
Homework questions:
Homework Questions Submittal CU Learn
September 1 & 3rd: Opioids and pain: Linda Watkins and Khara Ramos
Papers: Hutchin, EJN.TLR4.CCI, Hutchinson.TSWJ.07, TIPS 736
Homework Questions Submittal CU Learn
September 8 & 10th: Diagnostic aptamers and a Boulder Biotechnology company: Larry Gold
Papers: Gander et al. 2003 Zichi, Eaton, Singer, Gold 2008 AGAIN.pdf Tuerk and Gold 1990
Homework Questions Submittal CU Learn
September 15 & 17th: Tissue Engineering Principles and Practice: Kristi Anseth and Pete Mariner
9/22&9/24L. Leinwand: Personal Genomics
We will also break the class into 3 groups for the presentations on the 24th.
http://www.sciencemag.org/cgi/reprint/sci;317/5845/1687.pdf
http://www.nature.com/nature/journal/v456/n7218/pdf/456001a.pdf
http://www.personalgenomes.org/
These two classes will be devoted to exploring the new world of personal genomics. Please read the papers in Science and Nature and we will spend some time talking about
what personal genomics are, some discussion around ethical issues. We'll watch a short video and then you will have already been broken into 3 groups to research the following commercial services and you will give a report to the class on the 24th.
https://www.23andme.com/
http://www.navigenics.com
http://www.decodeme.com/
The kinds of things you want to report on are the services they provide; the cost; followup; do they try to collect lifestyle data; is there genetic counseling? is there value to their services? These are just suggestions for
the oral reports. You should make a PowerPoint presentation and each presentation should be about 15-17 minutes; so not much time, but I want each person to be part of the presentation.
Papers:
September 29 and October 1st: Alternatives to Gardasil and vaccine development: Bob Garcea
Papers: Gissmann_Garcea Zurhausen
October 6 & 8th: Life in a Biotech Company: Tim McKinsey and Chris Dufton
Papers:
cell systems and drug discovery.pdf
Galie_AmbrisentanTherapy_JAmCollCard_2005.pdf
GalieN_AmbrisentanFor_Circulation_2008.pdf
October 13 & 15th: How to use fruit flies to develop anti-cancer drugs: Tin Tin Su and Mara Stewart
Papers: Javelik and Combination Review
October 20 & 22nd: Eva Van Rooji MicroRNA Therapeutics for Muscle Disease
Papers: Elmen_Nature_2008_LNA_primates.pdf Krutzfeldt_Nature_2005.pdf Sense Antisense.pdf Thum_Nature_2008.pdf
October 27 & (29th: TBD)
October 27th
Careers with a degree in Life Sciences Panel Discussion.
Come prepared to ask questions of people in the following professions/professional schools:
MD/PhD
PhD
Science writing
Physician's Asst.
Veterinarian*
Pharmacy School*
*Invited, not yet confirmed
November 3 & 5th: Nicotine addiction and genetics: Marissa Ehringer/Holly Stephens
Papers: THORGEIRSSON_nature_2008.pdf, Saccone_HMG_2007 Schlaepfer_BP_2008
November 10 & 12th: Ken Krauter DNA Forensics: An old disappearance solved by new technology and the done in by technology!
Papers: SNPs_in_forensics_review ann_rev_genotype_methods
Finding Everett Ruess, DNA Test Results, and for fun the Evidence Photo Gallery, Map and Skull Reconstruction bullets at the top of the article on the homepage.
November 17 & 19th: Cancer treatments from a local Biotechnology Company: Richard Duke
Papers: Arai-PNAS (1997), Bianco_CGT03, Bellgrau et al and Duke, Nature.pdf
December 1: Designer drugs based on your genes: Brian Lowes
Dec. 3
presentations by groups 1,2,3
Dec. 8
presentations by groups 4,5,6
