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Michael Yarus

Michael Yarus

  • Professor

Porter B313B
Phone: (303) 492-8376

Office Location:

Education:

  1. Ph.D., California Institute of Technology, 1965

Biography:

Research Interests:

RNA structure and function; RNA catalysis; mechanisms of translation; origins of translation.

Research Profile:

This laboratory has engaged in three major types of scientific work:

  1. 1. on the fundamental reactions of the translational apparatus, and the roles of particular tRNA and mRNA sequences in translational efficiency and accuracy.
  1. 2. on the selection of particular RNA structures with binding or catalytic activity, and the relation of those activities to the origin of the genetic code, or translation in a larger sense.
  1. 3. on the nature of RNA affinity for phospholipid bilayers and on the role of such membrane RNAs in biology.

See PUBLICATIONS below for characteristic examples - in addition, selected complete manuscripts can be downloaded from the WEBSITE above.

Selected Publications:

On translation by RNAs alone.
Yarus, M   Cold Spring Harb Symp Quant Biol, 66:207-15.   2001
RNA-catalyzed amino acid activation.
Kumar, RK and Yarus, M   Biochemistry, 40(24):6998-7004.   2001
Simple, recurring RNA binding sites for L-arginine.
Janas, T, Widmann, JJ, Knight, R, and Yarus, M   RNA, 16(4):805-16.   2010
Multiple translational products from a five-nucleotide ribozyme.
Turk, RM, Chumachenko, NV, and Yarus, M   Proc Natl Acad Sci U S A, 107(10):4585-9.   2010
RNA-amino acid binding: a stereochemical era for the genetic code.
Yarus, M, Widmann, JJ, and Knight, R   J Mol Evol, 69(5):406-29.   2009
A membrane transporter for tryptophan composed of RNA.
Janas, T, Janas, T, and Yarus, M   RNA, 10(10):1541-9.   2004
Selection of the simplest RNA that binds isoleucine.
Lozupone, C, Changayil, S, Majerfeld, I, and Yarus, M   RNA, 9(11):1315-22.   2003
Acyl-CoAs from coenzyme ribozymes.
Jadhav, VR and Yarus, M   Biochemistry, 41(3):723-9.   2002
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