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Tin Tin Su

Tin Tin Su

  • Associate Professor
Room A220C
MCD Biology
347UCB, Colorado Ave.
Boulder, CO 80309-0347
Phone: (303) 735-3245

Websites:

Education:

  1. B.A., Mount Holyoke College, 1984
  2. Ph.D., Carnegie Mellon University, 1991

Biography:

Research Interests:

Cell-cycle regulation; checkpoints; radiation biology; using Drosophila for cancer drug screening

Research Profile:

Our goal is to understand how cells safe-guard their genetic information. We want to know how they do this during their normal course of life as well as when they become exposed to external insults like radiation that can damage DNA.  Loss of genetic information can result in death and disease. By understanding how cells safe-guard their genetic information, we may help prevent or treat diseases that result from loss of genetic information such as cancer.

We use Drosophila melanogaster (fruit fly) in our studies because it is a good model for human biology (read more about this).

Selected Publications:

Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae.
Jaklevic, BR and Su, TT   Curr Biol, 14(1):23-32.   2004
Regulation of mitosis in response to damaged or incompletely replicated DNA require different levels of Grapes (Drosophila Chk1).
Purdy, A, Uyetake, L, Cordeiro, MG, and Su, TT   J Cell Sci, 118(Pt 15):3305-15.   2005
Contribution of growth and cell cycle checkpoints to radiation survival in Drosophila.
Jaklevic, B, Uyetake, L, Lemstra, W, Chang, J, Leary, W, Edwards, A, Vidwans, S, Sibon, O, and Tin Su, T   Genetics, 174(4):1963-72.   2006
Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster. A. Wichmann, B. Jaklevic, and T. T. Su (2006) PNAS 103;9952-7
Wichmann, A, Jaklevic, B, and Su, TT   Proc Natl Acad Sci U S A, 103(26):9952-7.   2006
Drosophila Wee1 interacts with members of the gammaTURC and is required for proper mitotic-spindle morphogenesis and positioning.
Stumpff, J, Kellogg, DR, Krohne, KA, and Su, TT   Curr Biol, 15(17):1525-34.   2005
Why peer discussion improves student performance on in-class concept questions.
Smith, MK, Wood, WB, Adams, WK, Wieman, C, Knight, JK, Guild, N, and Su, TT   Science, 323(5910):122-4.   2009
Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila.
Jaklevic, B, Uyetake, L, Wichmann, A, Bilak, A, English, CN, and Su, TT   Dev Biol, 320(1):122-30.   2008
More Publications by Tin Tin Su
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