Warner JR, Copley SD, "Mechanism of the severe inhibition of tetrachlorohydroquinone dehalogenase by its aromatic substrates." Biochemistry 46 (2007): 4438-47
Warner JR, Lawson SL, Copley SD, "A mechanistic investigation of the thiol-disulfide exchange step in the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase." Biochemistry 44 (2005): 10360-8
Copley SD, Smith E, Morowitz HJ, "A mechanism for the association of amino acids with their codons and the origin of the genetic code." Proceedings of the National Academy of Sciences of the United States of America 102 (2005): 4442-7
Dai M, Ziesman S, Ratcliffe T, Gill RT, Copley SD, "Visualization of protoplast fusion and quantitation of recombination in fused protoplasts of auxotrophic strains of Escherichia coli." Metabolic engineering 7 (2005): 45-52
Cleland, C.E. & Copley, S.D., "The Possibility of Alternative Microbial Life on Earth." International Journal of Astrobiology 4 (2005): 165-173
Copley SD, Novak WR, Babbitt PC, "Divergence of function in the thioredoxin fold suprafamily: evidence for evolution of peroxiredoxins from a thioredoxin-like ancestor." Biochemistry 43 (2004): 13981-95
Dai M, Copley SD, "Genome shuffling improves degradation of the anthropogenic pesticide pentachlorophenol by Sphingobium chlorophenolicum ATCC 39723." Applied and environmental microbiology 70 (2004): 2391-7
Copley SD, "Enzymes with extra talents: moonlighting functions and catalytic promiscuity." Current opinion in chemical biology 7 (2003): 265-72
Dai M, Rogers JB, Warner JR, Copley SD, "A previously unrecognized step in pentachlorophenol degradation in Sphingobium chlorophenolicum is catalyzed by tetrachlorobenzoquinone reductase (PcpD)." Journal of bacteriology 185 (2003): 302-10
Copley, S. D. and Dhillon, J. K., "Lateral Gene Transfer and Parallel Evolution in the History of Glutathione Biosynthesis Genes" Genome Biology 3 (2002)
Kiefer PM, Copley SD, "Characterization of the initial steps in the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase." Biochemistry 41 (2002): 1315-22
Kiefer PM, McCarthy DL, Copley SD, "The reaction catalyzed by tetrachlorohydroquinone dehalogenase does not involve nucleophilic aromatic substitution." Biochemistry 41 (2002): 1308-14
Copley SD, "Evolution of a metabolic pathway for degradation of a toxic xenobiotic: the patchwork approach." Trends in biochemical sciences 25 (2000): 261-5
Anandarajah K, Kiefer PM, Donohoe BS, Copley SD, "Recruitment of a double bond isomerase to serve as a reductive dehalogenase during biodegradation of pentachlorophenol." Biochemistry 39 (2000): 5303-11
Fall R, Copley SD, "Bacterial sources and sinks of isoprene, a reactive atmospheric hydrocarbon." Environmental microbiology 2 (2000): 123-30
Xu L, Resing K, Lawson SL, Babbitt PC, Copley SD, "Evidence that pcpA encodes 2,6-dichlorohydroquinone dioxygenase, the ring cleavage enzyme required for pentachlorophenol degradation in Sphingomonas chlorophenolica strain ATCC 39723." Biochemistry 38 (1999): 7659-69
Copley SD, "Microbial dehalogenases: enzymes recruited to convert xenobiotic substrates." Current opinion in chemical biology 2 (1998): 613-7
McCarthy DL, Claude AA, Copley SD, "In vivo levels of chlorinated hydroquinones in a pentachlorophenol-degrading bacterium." Applied and environmental microbiology 63 (1997): 1883-8
Copley SD, "Diverse mechanistic approaches to difficult chemical transformations: microbial dehalogenation of chlorinated aromatic compounds." Chemistry & biology 4 (1997): 169-74
McCarthy, D. L.; Louie, D. F.; Copley, S. D., "Identification of a Covalent Intermediate Between Glutathione and Cys13 Formed During Catalysis by Tetrachlorohydroquinone Dehalogenase." J. Am. Chem. Soc. 119 (1997): 11337-11338
McCarthy DL, Navarrete S, Willett WS, Babbitt PC, Copley SD, "Exploration of the relationship between tetrachlorohydroquinone dehalogenase and the glutathione S-transferase superfamily." Biochemistry 35 (1996): 14634-42
Willett WS, Copley SD, "Identification and localization of a stable sulfenic acid in peroxide-treated tetrachlorohydroquinone dehalogenase using electrospray mass spectrometry." Chemistry & biology 3 (1996): 851-7
Crooks, G. P.; Xu, L.; Barkley, R. and Copley, S. D., "Exploration of possible mechanisms for 4-chlorobenzoyl CoA dehalogenase: Evidence for an aryl-enzyme intermediate" J. Am. Chem. Soc. 117 (1995): 10791-10798
Crooks GP, Copley SD, "Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1." Biochemistry 33 (1994): 11645-9
Crooks, G.P. ; Copley, S.D., "A Surprising Effect of Leaving Group on the Nucleophilic Aromatic Substitution Reaction Catalyzed by 4-Chlorobenzoyl CoA Dehalogenase" J. Am. Chem. Soc. 115 (1993): 6422-6423
Copley SD, Crooks GP, "Enzymic Dehalogenation of 4-Chlorobenzoyl Coenzyme A in Acinetobacter sp. Strain 4-CB1." Appl Environ Microbiol 58 (1992): 1385-1387
Copley SD, Frank E, Kirsch WM, Koch TH, "Detection and possible origins of aminomalonic acid in protein hydrolysates." Analytical biochemistry 201 (1992): 152-7
Copley, S. D. and Knowles, J. R., "The Conformational Equilibrium of Chorismate in Solution: Implications for the Mechanism of the Non-Enzymic and the Enzyme-Catalyzed Rearrangement of Chorismate to Prephenate." J. Am. Chem. Soc. 109 (1987): 5013-5018
Guilford, W. J.; Copley, S. D. and Knowles, J. R., "On the Mechanism of the Chorismate Mutase Reaction" J. Am. Chem. Soc. 109 (1987): 5013-5019
Copley, S. D. and Knowles, J. R., "The Uncatalyzed Claisen Rearrangement of Chorismate to Prephenate Prefers a Transition State of Chairlike Geometry." J. Am. Chem. Soc. 107 (1985): 5306-5308
Grimshaw, C. E.; Sogo, S. G.; Copley, S. D. and Knowles, J. R., "Synthesis of Stereoselectively Labeled [9-2H,3H] Chorismate and the Stereochemical Course of 5-Enolpyruvoyl shikimate-3-phosphate Synthetase." J. Am. Chem. Soc. 106 (1984): 2699-2700
Kovachy RJ, Copley SD, Allen RH, "Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase." The Journal of biological chemistry 258 (1983): 11415-21
Warner JR, Lawson SL, Copley SD, "A mechanistic investigation of the thiol-disulfide exchange step in the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase." Biochemistry 44 (2005): 10360-8
Copley SD, Smith E, Morowitz HJ, "A mechanism for the association of amino acids with their codons and the origin of the genetic code." Proceedings of the National Academy of Sciences of the United States of America 102 (2005): 4442-7
Dai M, Ziesman S, Ratcliffe T, Gill RT, Copley SD, "Visualization of protoplast fusion and quantitation of recombination in fused protoplasts of auxotrophic strains of Escherichia coli." Metabolic engineering 7 (2005): 45-52
Cleland, C.E. & Copley, S.D., "The Possibility of Alternative Microbial Life on Earth." International Journal of Astrobiology 4 (2005): 165-173
Copley SD, Novak WR, Babbitt PC, "Divergence of function in the thioredoxin fold suprafamily: evidence for evolution of peroxiredoxins from a thioredoxin-like ancestor." Biochemistry 43 (2004): 13981-95
Dai M, Copley SD, "Genome shuffling improves degradation of the anthropogenic pesticide pentachlorophenol by Sphingobium chlorophenolicum ATCC 39723." Applied and environmental microbiology 70 (2004): 2391-7
Copley SD, "Enzymes with extra talents: moonlighting functions and catalytic promiscuity." Current opinion in chemical biology 7 (2003): 265-72
Dai M, Rogers JB, Warner JR, Copley SD, "A previously unrecognized step in pentachlorophenol degradation in Sphingobium chlorophenolicum is catalyzed by tetrachlorobenzoquinone reductase (PcpD)." Journal of bacteriology 185 (2003): 302-10
Copley, S. D. and Dhillon, J. K., "Lateral Gene Transfer and Parallel Evolution in the History of Glutathione Biosynthesis Genes" Genome Biology 3 (2002)
Kiefer PM, Copley SD, "Characterization of the initial steps in the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase." Biochemistry 41 (2002): 1315-22
Kiefer PM, McCarthy DL, Copley SD, "The reaction catalyzed by tetrachlorohydroquinone dehalogenase does not involve nucleophilic aromatic substitution." Biochemistry 41 (2002): 1308-14
Copley SD, "Evolution of a metabolic pathway for degradation of a toxic xenobiotic: the patchwork approach." Trends in biochemical sciences 25 (2000): 261-5
Anandarajah K, Kiefer PM, Donohoe BS, Copley SD, "Recruitment of a double bond isomerase to serve as a reductive dehalogenase during biodegradation of pentachlorophenol." Biochemistry 39 (2000): 5303-11
Fall R, Copley SD, "Bacterial sources and sinks of isoprene, a reactive atmospheric hydrocarbon." Environmental microbiology 2 (2000): 123-30
Xu L, Resing K, Lawson SL, Babbitt PC, Copley SD, "Evidence that pcpA encodes 2,6-dichlorohydroquinone dioxygenase, the ring cleavage enzyme required for pentachlorophenol degradation in Sphingomonas chlorophenolica strain ATCC 39723." Biochemistry 38 (1999): 7659-69
Copley SD, "Microbial dehalogenases: enzymes recruited to convert xenobiotic substrates." Current opinion in chemical biology 2 (1998): 613-7
McCarthy DL, Claude AA, Copley SD, "In vivo levels of chlorinated hydroquinones in a pentachlorophenol-degrading bacterium." Applied and environmental microbiology 63 (1997): 1883-8
Copley SD, "Diverse mechanistic approaches to difficult chemical transformations: microbial dehalogenation of chlorinated aromatic compounds." Chemistry & biology 4 (1997): 169-74
McCarthy, D. L.; Louie, D. F.; Copley, S. D., "Identification of a Covalent Intermediate Between Glutathione and Cys13 Formed During Catalysis by Tetrachlorohydroquinone Dehalogenase." J. Am. Chem. Soc. 119 (1997): 11337-11338
McCarthy DL, Navarrete S, Willett WS, Babbitt PC, Copley SD, "Exploration of the relationship between tetrachlorohydroquinone dehalogenase and the glutathione S-transferase superfamily." Biochemistry 35 (1996): 14634-42
Willett WS, Copley SD, "Identification and localization of a stable sulfenic acid in peroxide-treated tetrachlorohydroquinone dehalogenase using electrospray mass spectrometry." Chemistry & biology 3 (1996): 851-7
Crooks, G. P.; Xu, L.; Barkley, R. and Copley, S. D., "Exploration of possible mechanisms for 4-chlorobenzoyl CoA dehalogenase: Evidence for an aryl-enzyme intermediate" J. Am. Chem. Soc. 117 (1995): 10791-10798
Crooks GP, Copley SD, "Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1." Biochemistry 33 (1994): 11645-9
Crooks, G.P. ; Copley, S.D., "A Surprising Effect of Leaving Group on the Nucleophilic Aromatic Substitution Reaction Catalyzed by 4-Chlorobenzoyl CoA Dehalogenase" J. Am. Chem. Soc. 115 (1993): 6422-6423
Copley SD, Crooks GP, "Enzymic Dehalogenation of 4-Chlorobenzoyl Coenzyme A in Acinetobacter sp. Strain 4-CB1." Appl Environ Microbiol 58 (1992): 1385-1387
Copley SD, Frank E, Kirsch WM, Koch TH, "Detection and possible origins of aminomalonic acid in protein hydrolysates." Analytical biochemistry 201 (1992): 152-7
Copley, S. D. and Knowles, J. R., "The Conformational Equilibrium of Chorismate in Solution: Implications for the Mechanism of the Non-Enzymic and the Enzyme-Catalyzed Rearrangement of Chorismate to Prephenate." J. Am. Chem. Soc. 109 (1987): 5013-5018
Guilford, W. J.; Copley, S. D. and Knowles, J. R., "On the Mechanism of the Chorismate Mutase Reaction" J. Am. Chem. Soc. 109 (1987): 5013-5019
Copley, S. D. and Knowles, J. R., "The Uncatalyzed Claisen Rearrangement of Chorismate to Prephenate Prefers a Transition State of Chairlike Geometry." J. Am. Chem. Soc. 107 (1985): 5306-5308
Grimshaw, C. E.; Sogo, S. G.; Copley, S. D. and Knowles, J. R., "Synthesis of Stereoselectively Labeled [9-2H,3H] Chorismate and the Stereochemical Course of 5-Enolpyruvoyl shikimate-3-phosphate Synthetase." J. Am. Chem. Soc. 106 (1984): 2699-2700
Kovachy RJ, Copley SD, Allen RH, "Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase." The Journal of biological chemistry 258 (1983): 11415-21
