Vicens Q, Gooding AR, Laederach A, Cech TR, "Local RNA structural changes induced by crystallization are revealed by SHAPE." RNA (New York, N.Y.) 13 (2007): 536-48
Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M, "The POT1-TPP1 telomere complex is a telomerase processivity factor." Nature 445 (2007): 506-10
Mozdy AD, Cech TR, "Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency." RNA (New York, N.Y.) 12 (2006): 1721-37
Guo F, Gooding AR, Cech TR, "Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme." RNA (New York, N.Y.) 12 (2006): 387-95
Jacobs SA, Podell ER, Cech TR, "Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase." Nature structural & molecular biology 13 (2006): 218-25
Vicens Q, Cech TR, "Atomic level architecture of group I introns revealed." Trends in biochemical sciences 31 (2006): 41-51
Zappulla DC, Goodrich K, Cech TR, "A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro." Nature structural & molecular biology 12 (2005): 1072-7
Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA, "POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates." The Journal of biological chemistry 280 (2005): 32069-80
Zaug AJ, Podell ER, Cech TR, "Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro." Proceedings of the National Academy of Sciences of the United States of America 102 (2005): 10864-9
Jacobs SA, Podell ER, Wuttke DS, Cech TR, "Soluble domains of telomerase reverse transcriptase identified by high-throughput screening." Protein science : a publication of the Protein Society 14 (2005): 2051-8
Lei M, Zaug AJ, Podell ER, Cech TR, "Switching human telomerase on and off with hPOT1 protein in vitro." The Journal of biological chemistry 280 (2005): 20449-56
Mandell JG, Goodrich KJ, Bähler J, Cech TR, "Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase." The Journal of biological chemistry 280 (2005): 5249-57
Lei M, Podell ER, Cech TR, "Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection." Nature structural & molecular biology 11 (2004): 1223-9
Guo F, Gooding AR, Cech TR, "Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site." Molecular cell 16 (2004): 351-62
Zappulla DC, Cech TR, "Yeast telomerase RNA: a flexible scaffold for protein subunits." Proceedings of the National Academy of Sciences of the United States of America 101 (2004): 10024-9
Aigner S, Cech TR, "The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro." RNA (New York, N.Y.) 10 (2004): 1108-18
Cech TR, "Beginning to understand the end of the chromosome." Cell 116 (2004): 273-9
Bryan TM, Goodrich KJ, Cech TR, "Tetrahymena telomerase is active as a monomer." Molecular biology of the cell 14 (2003): 4794-804
Lei M, Podell ER, Baumann P, Cech TR, "DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA." Nature 426 (2003): 198-203
Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR, "A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity." RNA (New York, N.Y.) 9 (2003): 1323-32
Classen S, Lyons D, Cech TR, Schultz SC, "Sequence-specific and 3'-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit." Biochemistry 42 (2003): 9269-77
Colgin LM, Baran K, Baumann P, Cech TR, Reddel RR, "Human POT1 facilitates telomere elongation by telomerase." Current biology 13 (2003): 942-6
Aigner S, Postberg J, Lipps HJ, Cech TR, "The Euplotes La motif protein p43 has properties of a telomerase-specific subunit." Biochemistry 42 (2003): 5736-47
Förstemann K, Zaug AJ, Cech TR, Lingner J, "Yeast telomerase is specialized for C/A-rich RNA templates." Nucleic acids research 31 (2003): 1646-55
Friedman KL, Heit JJ, Long DM, Cech TR, "N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex." Molecular biology of the cell 14 (2003): 1-13
Lei M, Baumann P, Cech TR, "Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe." Biochemistry 41 (2002): 14560-8
Seto AG, Livengood AJ, Tzfati Y, Blackburn EH, Cech TR, "A bulged stem tethers Est1p to telomerase RNA in budding yeast." Genes & development 16 (2002): 2800-12
Guo F, Cech TR, "Evolution of Tetrahymena ribozyme mutants with increased structural stability." Nature structural biology 9 (2002): 855-61
Baumann P, Podell E, Cech TR, "Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing." Molecular and cellular biology 22 (2002): 8079-87
Doudna JA, Cech TR, "The chemical repertoire of natural ribozymes." Nature 418 (2002): 222-8
Guo F, Cech TR, "In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron." RNA (New York, N.Y.) 8 (2002): 647-58
Livengood AJ, Zaug AJ, Cech TR, "Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction." Molecular and cellular biology 22 (2002): 2366-74
Jarstfer MB, Cech TR, "Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation." Biochemistry 41 (2002): 151-61
Sperger JM, Cech TR, "A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity." Biochemistry 40 (2001): 7005-16
Baumann P, Cech TR, "Pot1, the putative telomere end-binding protein in fission yeast and humans." Science (New York, N.Y.) 292 (2001): 1171-5
Juneau K, Podell E, Harrington DJ, Cech TR, "Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions." Structure (London, England : 1993) 9 (2001): 221-31
Silverman SK, Cech TR, "An early transition state for folding of the P4-P6 RNA domain." RNA (New York, N.Y.) 7 (2001): 161-6
Aigner S, Lingner J, Goodrich KJ, Grosshans CA, Shevchenko A, Mann M, Cech TR, "Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting." The EMBO journal 19 (2000): 6230-9
Silverman SK, Deras ML, Woodson SA, Scaringe SA, Cech TR, "Multiple folding pathways for the P4-P6 RNA domain." Biochemistry 39 (2000): 12465-75
Baumann P, Cech TR, "Protection of telomeres by the Ku protein in fission yeast." Molecular biology of the cell 11 (2000): 3265-75
Cech TR, "Structural biology. The ribosome is a ribozyme." Science (New York, N.Y.) 289 (2000): 878-9
Bryan TM, Goodrich KJ, Cech TR, "A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity." The Journal of biological chemistry 275 (2000): 24199-207
Bryan TM, Goodrich KJ, Cech TR, "Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase." Molecular cell 6 (2000): 493-9
Haering CH, Nakamura TM, Baumann P, Cech TR, "Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe." Proceedings of the National Academy of Sciences of the United States of America 97 (2000): 6367-72
Cech TR, "Life at the End of the Chromosome: Telomeres and Telomerase." Angew Chem Int Ed Engl 39 (2000): 34-43
Silverman SK, Zheng M, Wu M, Tinoco I, Cech TR, "Quantifying the energetic interplay of RNA tertiary and secondary structure interactions." RNA (New York, N.Y.) 5 (1999): 1665-74
Hagen M, Cech TR, "Self-splicing of the Tetrahymena intron from mRNA in mammalian cells." The EMBO journal 18 (1999): 6491-500
Friedman KL, Cech TR, "Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants." Genes & development 13 (1999): 2863-74
Silverman SK, Cech TR, "RNA tertiary folding monitored by fluorescence of covalently attached pyrene." Biochemistry 38 (1999): 14224-37
Seto AG, Zaug AJ, Sobel SG, Wolin SL, Cech TR, "Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle." Nature 401 (1999): 177-80
Juneau K, Cech TR, "In vitro selection of RNAs with increased tertiary structure stability." RNA (New York, N.Y.) 5 (1999): 1119-29
Silverman SK, Cech TR, "Energetics and cooperativity of tertiary hydrogen bonds in RNA structure." Biochemistry 38 (1999): 8691-702
Bryan TM, Cech TR, "Telomerase and the maintenance of chromosome ends." Current opinion in cell biology 11 (1999): 318-24
Jabri E, Cech TR, "In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity." RNA (New York, N.Y.) 4 (1998): 1481-92
Nakamura TM, Cooper JP, Cech TR, "Two modes of survival of fission yeast without telomerase." Science (New York, N.Y.) 282 (1998): 493-6
Golden BL, Gooding AR, Podell ER, Cech TR, "A preorganized active site in the crystal structure of the Tetrahymena ribozyme." Science (New York, N.Y.) 282 (1998): 259-64
Cohen SB, Cech TR, "A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps." RNA (New York, N.Y.) 4 (1998): 1179-85
Zhang B, Cech TR, "Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features." Chemistry & biology 5 (1998): 539-53
Szewczak AA, Podell ER, Bevilacqua PC, Cech TR, "Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis." Biochemistry 37 (1998): 11162-70
Bryan TM, Sperger JM, Chapman KB, Cech TR, "Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax." Proceedings of the National Academy of Sciences of the United States of America 95 (1998): 8479-84
Froelich-Ammon SJ, Dickinson BA, Bevilacqua JM, Schultz SC, Cech TR, "Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha." Genes & development 12 (1998): 1504-14
Bevilacqua PC, George CX, Samuel CE, Cech TR, "Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes." Biochemistry 37 (1998): 6303-16
Hammond PW, Cech TR, "Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation." Biochemistry 37 (1998): 5162-72
Lingner J, Cech TR, "Telomerase and chromosome end maintenance." Current opinion in genetics & development 8 (1998): 226-32
Nakamura TM, Cech TR, "Reversing time: origin of telomerase." Cell 92 (1998): 587-90
Jabri E, Aigner S, Cech TR, "Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis." Biochemistry 36 (1997): 16345-54
Zhang B, Cech TR, "Peptide bond formation by in vitro selected ribozymes." Nature 390 (1997): 96-100
Chapon C, Cech TR, Zaug AJ, "Polyadenylation of telomerase RNA in budding yeast." RNA (New York, N.Y.) 3 (1997): 1337-51
Lingner J, Cech TR, Hughes TR, Lundblad V, "Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity." Proceedings of the National Academy of Sciences of the United States of America 94 (1997): 11190-5
Hammond PW, Cech TR, "dGTP-dependent processivity and possible template switching of euplotes telomerase." Nucleic acids research 25 (1997): 3698-704
Tanner MA, Anderson EM, Gutell RR, Cech TR, "Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes." RNA (New York, N.Y.) 3 (1997): 1037-51
Weinstein LB, Jones BC, Cosstick R, Cech TR, "A second catalytic metal ion in group I ribozyme." Nature 388 (1997): 805-8
Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR, "Telomerase catalytic subunit homologs from fission yeast and human." Science (New York, N.Y.) 277 (1997): 955-9
Szewczak AA, Cech TR, "An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis." RNA (New York, N.Y.) 3 (1997): 838-49
Golden BL, Podell ER, Gooding AR, Cech TR, "Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron." Journal of molecular biology 270 (1997): 711-23
McConnell TS, Herschlag D, Cech TR, "Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction." Biochemistry 36 (1997): 8293-303
Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR, "Reverse transcriptase motifs in the catalytic subunit of telomerase." Science (New York, N.Y.) 276 (1997): 561-7
Cooper JP, Nimmo ER, Allshire RC, Cech TR, "Regulation of telomere length and function by a Myb-domain protein in fission yeast." Nature 385 (1997): 744-7
Tanner MA, Cech TR, "Joining the two domains of a group I ribozyme to form the catalytic core." Science (New York, N.Y.) 275 (1997): 847-9
Hammond PW, Lively TN, Cech TR, "The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers." Molecular and cellular biology 17 (1997): 296-308
Golden BL, Gooding AR, Podell ER, Cech TR, "X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering." RNA (New York, N.Y.) 2 (1996): 1295-305
Rusconi CP, Cech TR, "The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena." Genes & development 10 (1996): 2870-80
Kuo LY, Cech TR, "Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes." Nucleic acids research 24 (1996): 3722-7
Lingner J, Cech TR, "Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang." Proceedings of the National Academy of Sciences of the United States of America 93 (1996): 10712-7
Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA, "Crystal structure of a group I ribozyme domain: principles of RNA packing." Science (New York, N.Y.) 273 (1996): 1678-85
Campbell TB, Cech TR, "Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity." Biochemistry 35 (1996): 11493-502
Bevilacqua PC, Cech TR, "Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR." Biochemistry 35 (1996): 9983-94
Downs WD, Cech TR, "Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks." RNA (New York, N.Y.) 2 (1996): 718-32
Rusconi CP, Cech TR, "Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila." The EMBO journal 15 (1996): 3286-95
Cech TR, Szewczak AA, "Selecting apt RNAs for NMR." RNA (New York, N.Y.) 2 (1996): 625-7
Golden BL, Cech TR, "Conformational switches involved in orchestrating the successive steps of group I RNA splicing." Biochemistry 35 (1996): 3754-63
Zaug AJ, Linger J, Cech TR, "Method for determining RNA 3' ends and application to human telomerase RNA." Nucleic acids research 24 (1996): 532-3
Strobel SA, Cech TR, "Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization." Biochemistry 35 (1996): 1201-11
Weeks KM, Cech TR, "Assembly of a ribonucleoprotein catalyst by tertiary structure capture." Science (New York, N.Y.) 271 (1996): 345-8
Nakamura TM, Wang YH, Zaug AJ, Griffith JD, Cech TR, "Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy." The EMBO journal 14 (1995): 4849-59
Lingner J, Cooper JP, Cech TR, "Telomerase and DNA end replication: no longer a lagging strand problem?" Science (New York, N.Y.) 269 (1995): 1533-4
Campbell TB, Cech TR, "Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA." RNA (New York, N.Y.) 1 (1995): 598-609
Weeks KM, Cech TR, "Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain." Cell 82 (1995): 221-30
Fang G, Cech TR, "Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates." The Journal of cell biology 130 (1995): 243-53
Weeks KM, Cech TR, "Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron." Biochemistry 34 (1995): 7728-38
Hicke B, Rempel R, Maller J, Swank RA, Hamaguchi JR, Bradbury EM, Prescott DM, Cech TR, "Phosphorylation of the Oxytricha telomere protein: possible cell cycle regulation." Nucleic acids research 23 (1995): 1887-93
Zaug AJ, Cech TR, "Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA." RNA (New York, N.Y.) 1 (1995): 363-74
McConnell TS, Cech TR, "A positive entropy change for guanosine binding and for the chemical step in the Tetrahymena ribozyme reaction." Biochemistry 34 (1995): 4056-67
Doudna JA, Cech TR, Sullenger BA, "Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor." Proceedings of the National Academy of Sciences of the United States of America 92 (1995): 2355-9
Doudna JA, Cech TR, "Self-assembly of a group I intron active site from its component tertiary structural domains." RNA (New York, N.Y.) 1 (1995): 36-45
Strobel SA, Cech TR, "Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site." Science (New York, N.Y.) 267 (1995): 675-9
Zaug AJ, Dávila-Aponte JA, Cech TR, "Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu)." Biochemistry 33 (1994): 14935-47
Pyle AM, Moran S, Strobel SA, Chapman T, Turner DH, Cech TR, "Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity." Biochemistry 33 (1994): 13856-63
Strobel SA, Cech TR, Usman N, Beigelman L, "The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA." Biochemistry 33 (1994): 13824-35
Cech TR, "Chromosome end games." Science (New York, N.Y.) 266 (1994): 387-8
Sullenger BA, Cech TR, "Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing." Nature 371 (1994): 619-22
Murphy FL, Wang YH, Griffith JD, Cech TR, "Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme." Science (New York, N.Y.) 265 (1994): 1709-12
Lingner J, Hendrick LL, Cech TR, "Telomerase RNAs of different ciliates have a common secondary structure and a permuted template." Genes & development 8 (1994): 1984-98
Laggerbauer B, Murphy FL, Cech TR, "Two major tertiary folding transitions of the Tetrahymena catalytic RNA." The EMBO journal 13 (1994): 2669-76
Downs WD, Cech TR, "A tertiary interaction in the Tetrahymena intron contributes to selection of the 5' splice site." Genes & development 8 (1994): 1198-211
Cech TR, Damberger SH, Gutell RR, "Representation of the secondary and tertiary structure of group I introns." Nature structural biology 1 (1994): 273-80
Hicke BJ, Willis MC, Koch TH, Cech TR, "Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine." Biochemistry 33 (1994): 3364-73
Murphy FL, Cech TR, "GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain." Journal of molecular biology 236 (1994): 49-63
Wang YH, Murphy FL, Cech TR, Griffith JD, "Visualization of a tertiary structural domain of the Tetrahymena group I intron by electron microscopy." Journal of molecular biology 236 (1994): 64-71
Strobel SA, Cech TR, "Translocation of an RNA duplex on a ribozyme." Nature structural biology 1 (1994): 13-7
Cech TR, "The efficiency and versatility of catalytic RNA: implications for an RNA world." Gene 135 (1993): 33-6
Strobel SA, Cech TR, "Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme." Biochemistry 32 (1993): 13593-604
Sullenger BA, Cech TR, "Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA." Science (New York, N.Y.) 262 (1993): 1566-9
Willis MC, Hicke BJ, Uhlenbeck OC, Cech TR, Koch TH, "Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins." Science (New York, N.Y.) 262 (1993): 1255-7
Fang G, Cech TR, "Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein." Biochemistry 32 (1993): 11646-57
McConnell TS, Cech TR, Herschlag D, "Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding." Proceedings of the National Academy of Sciences of the United States of America 90 (1993): 8362-6
Fang G, Cech TR, "The beta subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA." Cell 74 (1993): 875-85
Herschlag D, Eckstein F, Cech TR, "Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA." Biochemistry 32 (1993): 8299-311
Herschlag D, Eckstein F, Cech TR, "The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction." Biochemistry 32 (1993): 8312-21
Zaug AJ, McEvoy MM, Cech TR, "Self-splicing of the group I intron from Anabaena pre-tRNA: requirement for base-pairing of the exons in the anticodon stem." Biochemistry 32 (1993): 7946-53
Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR, "Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n." Molecular and cellular biology 13 (1993): 4301-10
Fang G, Cech TR, "Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits." Proceedings of the National Academy of Sciences of the United States of America 90 (1993): 6056-60
Murphy FL, Cech TR, "An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme." Biochemistry 32 (1993): 5291-300
Cech TR, "Catalytic RNA: structure and mechanism." Biochemical Society transactions 21 (1993): 229-34
Fang G, Gray JT, Cech TR, "Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit." Genes & development 7 (1993): 870-82
Wang JF, Downs WD, Cech TR, "Movement of the guide sequence during RNA catalysis by a group I ribozyme." Science (New York, N.Y.) 260 (1993): 504-8
Piccirilli JA, Vyle JS, Caruthers MH, Cech TR, "Metal ion catalysis in the Tetrahymena ribozyme reaction." Nature 361 (1993): 85-8
Legault P, Herschlag D, Celander DW, Cech TR, "Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis." Nucleic acids research 20 (1992): 6613-9
Cech TR, Herschlag D, Piccirilli JA, Pyle AM, "RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization." The Journal of biological chemistry 267 (1992): 17479-82
Pyle AM, Murphy FL, Cech TR, "RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme." Nature 358 (1992): 123-8
Piccirilli JA, McConnell TS, Zaug AJ, Noller HF, Cech TR, "Aminoacyl esterase activity of the Tetrahymena ribozyme." Science (New York, N.Y.) 256 (1992): 1420-4
Wang JF, Cech TR, "Tertiary structure around the guanosine-binding site of the Tetrahymena ribozyme." Science (New York, N.Y.) 256 (1992): 526-9
Heuer TS, Chandry PS, Belfort M, Celander DW, Cech TR, "Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core." Proceedings of the National Academy of Sciences of the United States of America 88 (1991): 11105-9
Young B, Herschlag D, Cech TR, "Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity." Cell 67 (1991): 1007-19
Gray JT, Celander DW, Price CM, Cech TR, "Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex." Cell 67 (1991): 807-14
Fang GW, Cech TR, "Molecular cloning of telomere-binding protein genes from Stylonychia mytilis." Nucleic acids research 19 (1991): 5515-8
Gampel A, Cech TR, "Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA." Genes & development 5 (1991): 1870-80
Dávila-Aponte JA, Huss VA, Sogin ML, Cech TR, "A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus." Nucleic acids research 19 (1991): 4429-36
Grosshans CA, Cech TR, "A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3' end blocked for transesterification." Nucleic acids research 19 (1991): 3875-80
Herschlag D, Piccirilli JA, Cech TR, "Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom." Biochemistry 30 (1991): 4844-54
Zahler AM, Williamson JR, Cech TR, Prescott DM, "Inhibition of telomerase by G-quartet DNA structures." Nature 350 (1991): 718-20
Pyle AM, Cech TR, "Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups." Nature 350 (1991): 628-31
Woodson SA, Cech TR, "Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA." Biochemistry 30 (1991): 2042-50
Cech TR, "RNA editing: world's smallest introns?" Cell 64 (1991): 667-9
Celander DW, Cech TR, "Visualizing the higher order folding of a catalytic RNA molecule." Science (New York, N.Y.) 251 (1991): 401-7
Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M, "The POT1-TPP1 telomere complex is a telomerase processivity factor." Nature 445 (2007): 506-10
Mozdy AD, Cech TR, "Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency." RNA (New York, N.Y.) 12 (2006): 1721-37
Guo F, Gooding AR, Cech TR, "Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme." RNA (New York, N.Y.) 12 (2006): 387-95
Jacobs SA, Podell ER, Cech TR, "Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase." Nature structural & molecular biology 13 (2006): 218-25
Vicens Q, Cech TR, "Atomic level architecture of group I introns revealed." Trends in biochemical sciences 31 (2006): 41-51
Zappulla DC, Goodrich K, Cech TR, "A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro." Nature structural & molecular biology 12 (2005): 1072-7
Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA, "POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates." The Journal of biological chemistry 280 (2005): 32069-80
Zaug AJ, Podell ER, Cech TR, "Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro." Proceedings of the National Academy of Sciences of the United States of America 102 (2005): 10864-9
Jacobs SA, Podell ER, Wuttke DS, Cech TR, "Soluble domains of telomerase reverse transcriptase identified by high-throughput screening." Protein science : a publication of the Protein Society 14 (2005): 2051-8
Lei M, Zaug AJ, Podell ER, Cech TR, "Switching human telomerase on and off with hPOT1 protein in vitro." The Journal of biological chemistry 280 (2005): 20449-56
Mandell JG, Goodrich KJ, Bähler J, Cech TR, "Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase." The Journal of biological chemistry 280 (2005): 5249-57
Lei M, Podell ER, Cech TR, "Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection." Nature structural & molecular biology 11 (2004): 1223-9
Guo F, Gooding AR, Cech TR, "Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site." Molecular cell 16 (2004): 351-62
Zappulla DC, Cech TR, "Yeast telomerase RNA: a flexible scaffold for protein subunits." Proceedings of the National Academy of Sciences of the United States of America 101 (2004): 10024-9
Aigner S, Cech TR, "The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro." RNA (New York, N.Y.) 10 (2004): 1108-18
Cech TR, "Beginning to understand the end of the chromosome." Cell 116 (2004): 273-9
Bryan TM, Goodrich KJ, Cech TR, "Tetrahymena telomerase is active as a monomer." Molecular biology of the cell 14 (2003): 4794-804
Lei M, Podell ER, Baumann P, Cech TR, "DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA." Nature 426 (2003): 198-203
Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR, "A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity." RNA (New York, N.Y.) 9 (2003): 1323-32
Classen S, Lyons D, Cech TR, Schultz SC, "Sequence-specific and 3'-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit." Biochemistry 42 (2003): 9269-77
Colgin LM, Baran K, Baumann P, Cech TR, Reddel RR, "Human POT1 facilitates telomere elongation by telomerase." Current biology 13 (2003): 942-6
Aigner S, Postberg J, Lipps HJ, Cech TR, "The Euplotes La motif protein p43 has properties of a telomerase-specific subunit." Biochemistry 42 (2003): 5736-47
Förstemann K, Zaug AJ, Cech TR, Lingner J, "Yeast telomerase is specialized for C/A-rich RNA templates." Nucleic acids research 31 (2003): 1646-55
Friedman KL, Heit JJ, Long DM, Cech TR, "N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex." Molecular biology of the cell 14 (2003): 1-13
Lei M, Baumann P, Cech TR, "Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe." Biochemistry 41 (2002): 14560-8
Seto AG, Livengood AJ, Tzfati Y, Blackburn EH, Cech TR, "A bulged stem tethers Est1p to telomerase RNA in budding yeast." Genes & development 16 (2002): 2800-12
Guo F, Cech TR, "Evolution of Tetrahymena ribozyme mutants with increased structural stability." Nature structural biology 9 (2002): 855-61
Baumann P, Podell E, Cech TR, "Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing." Molecular and cellular biology 22 (2002): 8079-87
Doudna JA, Cech TR, "The chemical repertoire of natural ribozymes." Nature 418 (2002): 222-8
Guo F, Cech TR, "In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron." RNA (New York, N.Y.) 8 (2002): 647-58
Livengood AJ, Zaug AJ, Cech TR, "Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction." Molecular and cellular biology 22 (2002): 2366-74
Jarstfer MB, Cech TR, "Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation." Biochemistry 41 (2002): 151-61
Sperger JM, Cech TR, "A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity." Biochemistry 40 (2001): 7005-16
Baumann P, Cech TR, "Pot1, the putative telomere end-binding protein in fission yeast and humans." Science (New York, N.Y.) 292 (2001): 1171-5
Juneau K, Podell E, Harrington DJ, Cech TR, "Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions." Structure (London, England : 1993) 9 (2001): 221-31
Silverman SK, Cech TR, "An early transition state for folding of the P4-P6 RNA domain." RNA (New York, N.Y.) 7 (2001): 161-6
Aigner S, Lingner J, Goodrich KJ, Grosshans CA, Shevchenko A, Mann M, Cech TR, "Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting." The EMBO journal 19 (2000): 6230-9
Silverman SK, Deras ML, Woodson SA, Scaringe SA, Cech TR, "Multiple folding pathways for the P4-P6 RNA domain." Biochemistry 39 (2000): 12465-75
Baumann P, Cech TR, "Protection of telomeres by the Ku protein in fission yeast." Molecular biology of the cell 11 (2000): 3265-75
Cech TR, "Structural biology. The ribosome is a ribozyme." Science (New York, N.Y.) 289 (2000): 878-9
Bryan TM, Goodrich KJ, Cech TR, "A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity." The Journal of biological chemistry 275 (2000): 24199-207
Bryan TM, Goodrich KJ, Cech TR, "Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase." Molecular cell 6 (2000): 493-9
Haering CH, Nakamura TM, Baumann P, Cech TR, "Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe." Proceedings of the National Academy of Sciences of the United States of America 97 (2000): 6367-72
Cech TR, "Life at the End of the Chromosome: Telomeres and Telomerase." Angew Chem Int Ed Engl 39 (2000): 34-43
Silverman SK, Zheng M, Wu M, Tinoco I, Cech TR, "Quantifying the energetic interplay of RNA tertiary and secondary structure interactions." RNA (New York, N.Y.) 5 (1999): 1665-74
Hagen M, Cech TR, "Self-splicing of the Tetrahymena intron from mRNA in mammalian cells." The EMBO journal 18 (1999): 6491-500
Friedman KL, Cech TR, "Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants." Genes & development 13 (1999): 2863-74
Silverman SK, Cech TR, "RNA tertiary folding monitored by fluorescence of covalently attached pyrene." Biochemistry 38 (1999): 14224-37
Seto AG, Zaug AJ, Sobel SG, Wolin SL, Cech TR, "Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle." Nature 401 (1999): 177-80
Juneau K, Cech TR, "In vitro selection of RNAs with increased tertiary structure stability." RNA (New York, N.Y.) 5 (1999): 1119-29
Silverman SK, Cech TR, "Energetics and cooperativity of tertiary hydrogen bonds in RNA structure." Biochemistry 38 (1999): 8691-702
Bryan TM, Cech TR, "Telomerase and the maintenance of chromosome ends." Current opinion in cell biology 11 (1999): 318-24
Jabri E, Cech TR, "In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity." RNA (New York, N.Y.) 4 (1998): 1481-92
Nakamura TM, Cooper JP, Cech TR, "Two modes of survival of fission yeast without telomerase." Science (New York, N.Y.) 282 (1998): 493-6
Golden BL, Gooding AR, Podell ER, Cech TR, "A preorganized active site in the crystal structure of the Tetrahymena ribozyme." Science (New York, N.Y.) 282 (1998): 259-64
Cohen SB, Cech TR, "A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps." RNA (New York, N.Y.) 4 (1998): 1179-85
Zhang B, Cech TR, "Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features." Chemistry & biology 5 (1998): 539-53
Szewczak AA, Podell ER, Bevilacqua PC, Cech TR, "Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis." Biochemistry 37 (1998): 11162-70
Bryan TM, Sperger JM, Chapman KB, Cech TR, "Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax." Proceedings of the National Academy of Sciences of the United States of America 95 (1998): 8479-84
Froelich-Ammon SJ, Dickinson BA, Bevilacqua JM, Schultz SC, Cech TR, "Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha." Genes & development 12 (1998): 1504-14
Bevilacqua PC, George CX, Samuel CE, Cech TR, "Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes." Biochemistry 37 (1998): 6303-16
Hammond PW, Cech TR, "Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation." Biochemistry 37 (1998): 5162-72
Lingner J, Cech TR, "Telomerase and chromosome end maintenance." Current opinion in genetics & development 8 (1998): 226-32
Nakamura TM, Cech TR, "Reversing time: origin of telomerase." Cell 92 (1998): 587-90
Jabri E, Aigner S, Cech TR, "Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis." Biochemistry 36 (1997): 16345-54
Zhang B, Cech TR, "Peptide bond formation by in vitro selected ribozymes." Nature 390 (1997): 96-100
Chapon C, Cech TR, Zaug AJ, "Polyadenylation of telomerase RNA in budding yeast." RNA (New York, N.Y.) 3 (1997): 1337-51
Lingner J, Cech TR, Hughes TR, Lundblad V, "Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity." Proceedings of the National Academy of Sciences of the United States of America 94 (1997): 11190-5
Hammond PW, Cech TR, "dGTP-dependent processivity and possible template switching of euplotes telomerase." Nucleic acids research 25 (1997): 3698-704
Tanner MA, Anderson EM, Gutell RR, Cech TR, "Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes." RNA (New York, N.Y.) 3 (1997): 1037-51
Weinstein LB, Jones BC, Cosstick R, Cech TR, "A second catalytic metal ion in group I ribozyme." Nature 388 (1997): 805-8
Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR, "Telomerase catalytic subunit homologs from fission yeast and human." Science (New York, N.Y.) 277 (1997): 955-9
Szewczak AA, Cech TR, "An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis." RNA (New York, N.Y.) 3 (1997): 838-49
Golden BL, Podell ER, Gooding AR, Cech TR, "Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron." Journal of molecular biology 270 (1997): 711-23
McConnell TS, Herschlag D, Cech TR, "Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction." Biochemistry 36 (1997): 8293-303
Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR, "Reverse transcriptase motifs in the catalytic subunit of telomerase." Science (New York, N.Y.) 276 (1997): 561-7
Cooper JP, Nimmo ER, Allshire RC, Cech TR, "Regulation of telomere length and function by a Myb-domain protein in fission yeast." Nature 385 (1997): 744-7
Tanner MA, Cech TR, "Joining the two domains of a group I ribozyme to form the catalytic core." Science (New York, N.Y.) 275 (1997): 847-9
Hammond PW, Lively TN, Cech TR, "The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers." Molecular and cellular biology 17 (1997): 296-308
Golden BL, Gooding AR, Podell ER, Cech TR, "X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering." RNA (New York, N.Y.) 2 (1996): 1295-305
Rusconi CP, Cech TR, "The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena." Genes & development 10 (1996): 2870-80
Kuo LY, Cech TR, "Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes." Nucleic acids research 24 (1996): 3722-7
Lingner J, Cech TR, "Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang." Proceedings of the National Academy of Sciences of the United States of America 93 (1996): 10712-7
Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA, "Crystal structure of a group I ribozyme domain: principles of RNA packing." Science (New York, N.Y.) 273 (1996): 1678-85
Campbell TB, Cech TR, "Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity." Biochemistry 35 (1996): 11493-502
Bevilacqua PC, Cech TR, "Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR." Biochemistry 35 (1996): 9983-94
Downs WD, Cech TR, "Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks." RNA (New York, N.Y.) 2 (1996): 718-32
Rusconi CP, Cech TR, "Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila." The EMBO journal 15 (1996): 3286-95
Cech TR, Szewczak AA, "Selecting apt RNAs for NMR." RNA (New York, N.Y.) 2 (1996): 625-7
Golden BL, Cech TR, "Conformational switches involved in orchestrating the successive steps of group I RNA splicing." Biochemistry 35 (1996): 3754-63
Zaug AJ, Linger J, Cech TR, "Method for determining RNA 3' ends and application to human telomerase RNA." Nucleic acids research 24 (1996): 532-3
Strobel SA, Cech TR, "Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization." Biochemistry 35 (1996): 1201-11
Weeks KM, Cech TR, "Assembly of a ribonucleoprotein catalyst by tertiary structure capture." Science (New York, N.Y.) 271 (1996): 345-8
Nakamura TM, Wang YH, Zaug AJ, Griffith JD, Cech TR, "Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy." The EMBO journal 14 (1995): 4849-59
Lingner J, Cooper JP, Cech TR, "Telomerase and DNA end replication: no longer a lagging strand problem?" Science (New York, N.Y.) 269 (1995): 1533-4
Campbell TB, Cech TR, "Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA." RNA (New York, N.Y.) 1 (1995): 598-609
Weeks KM, Cech TR, "Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain." Cell 82 (1995): 221-30
Fang G, Cech TR, "Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates." The Journal of cell biology 130 (1995): 243-53
Weeks KM, Cech TR, "Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron." Biochemistry 34 (1995): 7728-38
Hicke B, Rempel R, Maller J, Swank RA, Hamaguchi JR, Bradbury EM, Prescott DM, Cech TR, "Phosphorylation of the Oxytricha telomere protein: possible cell cycle regulation." Nucleic acids research 23 (1995): 1887-93
Zaug AJ, Cech TR, "Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA." RNA (New York, N.Y.) 1 (1995): 363-74
McConnell TS, Cech TR, "A positive entropy change for guanosine binding and for the chemical step in the Tetrahymena ribozyme reaction." Biochemistry 34 (1995): 4056-67
Doudna JA, Cech TR, Sullenger BA, "Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor." Proceedings of the National Academy of Sciences of the United States of America 92 (1995): 2355-9
Doudna JA, Cech TR, "Self-assembly of a group I intron active site from its component tertiary structural domains." RNA (New York, N.Y.) 1 (1995): 36-45
Strobel SA, Cech TR, "Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site." Science (New York, N.Y.) 267 (1995): 675-9
Zaug AJ, Dávila-Aponte JA, Cech TR, "Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu)." Biochemistry 33 (1994): 14935-47
Pyle AM, Moran S, Strobel SA, Chapman T, Turner DH, Cech TR, "Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity." Biochemistry 33 (1994): 13856-63
Strobel SA, Cech TR, Usman N, Beigelman L, "The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA." Biochemistry 33 (1994): 13824-35
Cech TR, "Chromosome end games." Science (New York, N.Y.) 266 (1994): 387-8
Sullenger BA, Cech TR, "Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing." Nature 371 (1994): 619-22
Murphy FL, Wang YH, Griffith JD, Cech TR, "Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme." Science (New York, N.Y.) 265 (1994): 1709-12
Lingner J, Hendrick LL, Cech TR, "Telomerase RNAs of different ciliates have a common secondary structure and a permuted template." Genes & development 8 (1994): 1984-98
Laggerbauer B, Murphy FL, Cech TR, "Two major tertiary folding transitions of the Tetrahymena catalytic RNA." The EMBO journal 13 (1994): 2669-76
Downs WD, Cech TR, "A tertiary interaction in the Tetrahymena intron contributes to selection of the 5' splice site." Genes & development 8 (1994): 1198-211
Cech TR, Damberger SH, Gutell RR, "Representation of the secondary and tertiary structure of group I introns." Nature structural biology 1 (1994): 273-80
Hicke BJ, Willis MC, Koch TH, Cech TR, "Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine." Biochemistry 33 (1994): 3364-73
Murphy FL, Cech TR, "GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain." Journal of molecular biology 236 (1994): 49-63
Wang YH, Murphy FL, Cech TR, Griffith JD, "Visualization of a tertiary structural domain of the Tetrahymena group I intron by electron microscopy." Journal of molecular biology 236 (1994): 64-71
Strobel SA, Cech TR, "Translocation of an RNA duplex on a ribozyme." Nature structural biology 1 (1994): 13-7
Cech TR, "The efficiency and versatility of catalytic RNA: implications for an RNA world." Gene 135 (1993): 33-6
Strobel SA, Cech TR, "Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme." Biochemistry 32 (1993): 13593-604
Sullenger BA, Cech TR, "Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA." Science (New York, N.Y.) 262 (1993): 1566-9
Willis MC, Hicke BJ, Uhlenbeck OC, Cech TR, Koch TH, "Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins." Science (New York, N.Y.) 262 (1993): 1255-7
Fang G, Cech TR, "Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein." Biochemistry 32 (1993): 11646-57
McConnell TS, Cech TR, Herschlag D, "Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding." Proceedings of the National Academy of Sciences of the United States of America 90 (1993): 8362-6
Fang G, Cech TR, "The beta subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA." Cell 74 (1993): 875-85
Herschlag D, Eckstein F, Cech TR, "Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA." Biochemistry 32 (1993): 8299-311
Herschlag D, Eckstein F, Cech TR, "The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction." Biochemistry 32 (1993): 8312-21
Zaug AJ, McEvoy MM, Cech TR, "Self-splicing of the group I intron from Anabaena pre-tRNA: requirement for base-pairing of the exons in the anticodon stem." Biochemistry 32 (1993): 7946-53
Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR, "Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n." Molecular and cellular biology 13 (1993): 4301-10
Fang G, Cech TR, "Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits." Proceedings of the National Academy of Sciences of the United States of America 90 (1993): 6056-60
Murphy FL, Cech TR, "An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme." Biochemistry 32 (1993): 5291-300
Cech TR, "Catalytic RNA: structure and mechanism." Biochemical Society transactions 21 (1993): 229-34
Fang G, Gray JT, Cech TR, "Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit." Genes & development 7 (1993): 870-82
Wang JF, Downs WD, Cech TR, "Movement of the guide sequence during RNA catalysis by a group I ribozyme." Science (New York, N.Y.) 260 (1993): 504-8
Piccirilli JA, Vyle JS, Caruthers MH, Cech TR, "Metal ion catalysis in the Tetrahymena ribozyme reaction." Nature 361 (1993): 85-8
Legault P, Herschlag D, Celander DW, Cech TR, "Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis." Nucleic acids research 20 (1992): 6613-9
Cech TR, Herschlag D, Piccirilli JA, Pyle AM, "RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization." The Journal of biological chemistry 267 (1992): 17479-82
Pyle AM, Murphy FL, Cech TR, "RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme." Nature 358 (1992): 123-8
Piccirilli JA, McConnell TS, Zaug AJ, Noller HF, Cech TR, "Aminoacyl esterase activity of the Tetrahymena ribozyme." Science (New York, N.Y.) 256 (1992): 1420-4
Wang JF, Cech TR, "Tertiary structure around the guanosine-binding site of the Tetrahymena ribozyme." Science (New York, N.Y.) 256 (1992): 526-9
Heuer TS, Chandry PS, Belfort M, Celander DW, Cech TR, "Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core." Proceedings of the National Academy of Sciences of the United States of America 88 (1991): 11105-9
Young B, Herschlag D, Cech TR, "Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity." Cell 67 (1991): 1007-19
Gray JT, Celander DW, Price CM, Cech TR, "Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex." Cell 67 (1991): 807-14
Fang GW, Cech TR, "Molecular cloning of telomere-binding protein genes from Stylonychia mytilis." Nucleic acids research 19 (1991): 5515-8
Gampel A, Cech TR, "Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA." Genes & development 5 (1991): 1870-80
Dávila-Aponte JA, Huss VA, Sogin ML, Cech TR, "A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus." Nucleic acids research 19 (1991): 4429-36
Grosshans CA, Cech TR, "A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3' end blocked for transesterification." Nucleic acids research 19 (1991): 3875-80
Herschlag D, Piccirilli JA, Cech TR, "Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom." Biochemistry 30 (1991): 4844-54
Zahler AM, Williamson JR, Cech TR, Prescott DM, "Inhibition of telomerase by G-quartet DNA structures." Nature 350 (1991): 718-20
Pyle AM, Cech TR, "Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups." Nature 350 (1991): 628-31
Woodson SA, Cech TR, "Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA." Biochemistry 30 (1991): 2042-50
Cech TR, "RNA editing: world's smallest introns?" Cell 64 (1991): 667-9
Celander DW, Cech TR, "Visualizing the higher order folding of a catalytic RNA molecule." Science (New York, N.Y.) 251 (1991): 401-7