Welcome to the Dowell lab at the University of Colorado in the Department of MCD Biology. We are also affiliated with the Department of Computer Science and the School of Medicine's Computational Bioscience Program.
Our research focuses on developing informative, mechanistic models that unravel biologically meaningful information from a few individuals and limited reference information. We leverage comparative information to better understand both the diverse roles that non-coding transcripts play within the cell and the impact of variation on phenotype between closely related individuals.
[More about our current research interests...]
Transcription factor binding variation in the evolution of gene regulation
R.D. Dowell
Trends in Genetics 26(11):468-475 (2010)
[abstract]Regulatory Overlapping RNA Transcripts
T. Danford, R. Dowell, S. Agarwala, P. Grisafi, G. Fink, D. Gifford
14th Annual International Conference, RECOMB LNBI 6044:110-122 (2010)
Feed-forward Regulation of a Cell Fate Determinant by an RNA-binding Protein Generates Asymmetry in Yeast
J.J. Wolf, R.D. Dowell, S. Mahony, M. Rabani, D.K. Gifford, G.R. Fink
Genetics, 185:513-522 (2010)
[abstract] [reprint (Subscription Required)] [Supplemental Material]
Genotype to Phenotype: A Complex Problem
R.D. Dowell*, O. Ryan*, A. Jansen, D. Cheung, S. Agarwala, T. Danford, D.A. Bernstein, P.A. Rolfe, L.E. Heisler,B. Chin, C. Nislow, G. Giaever, P.C. Phillips, G.R. Fink, D.K. Gifford, C. Boone
Science, 328(5977):469 (2010)
[abstract] [reprint (Subscription Required)] [Supplemental Website]
Toggle involving cis-interfering noncoding RNAs controls variegated gene expression in yeast
S.L. Bumgarner, R.D. Dowell, P. Grisafi, D.K. Gifford, and G.R. Fink
PNAS, 106(43):18321-18326 (2009)
[abstract] [reprint (Subscription Required)] [Commentary by Fred Winston]
[More about our publications...]
Dept. of MCD Biology
University of Colorado
347 UCB
Boulder, CO 80309, USA
