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THE XUE LAB

Innovative use of the C.elegans model in diverse research fields

 

 

 

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The Xue Laboratory was founded in the fall of 1997 with the express goal of studying the genetic and molecular mechanisms of programmed cell death. The laboratory has made numerous important contributions not just to the field of programmed cell death, but has extended its reach to several diverse research fields. The Xue Lab has recently refined its focus to four major research areas: continued advanced research in the field of programmed cell death, study of the genetics and molecular mechanisms that establish and maintain phospholipid asymmetry, characterization of parental mitochondria elimination during early development, and the use of C. elegans as an animal model to study human disease and to perform drug discovery. In these pursuits the lab has very recently made significant contributions to our understanding of the mechanism of action of Hepatitis B Virus X protein, made key discoveries in the field of phosphotidylserine asymmetry and externalization (see below video). Beyond these contributions the Xue Lab has also recently made important discoveries in characterizing the chromosome fragmentation process during apoptosis, including the identification of the caspase-dependent conversion of the dicer ribonuclease into a deoxyribonuclease and multiple apoptotic nucleases involved in the process. We hope to continue to provide contributions to a wide array of research fields. For more detailed information about the projects studied by the Xue Lab, please see our Projects page. For a more generalized research overview please see our general research description. To contact the Xue Lab please proceed to Contact page.

 

 

Analysis of activation, execution, and engulfment in C. elegans embryo apoptosis

 

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A secreted Annexin GFP sensor labels surface-exposed PS during apoptosis

 

 

Analysis of paternal mitochondria elimination in a wild-type C. elegans embryo

 

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MitoTracker Red-stained paternal mitochondria are eliminated during early embryogenesis