Tin Tin Su - Associate Professor
Ph.D., Carnegie Mellon University, 1991
Cell-cycle regulation in Drosophila; checkpoints.
Our goal is to understand how cells safe-guard their genetic information. We want to know how they do this during their normal course of life as well as when they become exposed to external insults like radiation that can damage DNA. Loss of genetic information can result in death and disease. By understanding how cells safe-guard their genetic information, we may help prevent or treat diseases that result from loss of genetic information such as cancer.
We use Drosophila melanogaster (fruit fly) in our studies because it is a good model for human biology (read more about this).
MCDB
(303) 735-3245 (lab) 735-2837
send e-mail
MCDB A220C
LaRocque JR, Jaklevic B, Su TT, Sekelsky J, "Drosophila ATR in double-strand break repair." Genetics 175 (2007): 1023-33
Garcia K, Duncan T, Su TT, "Analysis of the cell division cycle in Drosophila." Methods (San Diego, Calif.) 41 (2007): 198-205
Wichmann A, Jaklevic B, Su TT, "Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster." Proceedings of the National Academy of Sciences of the United States of America 103 (2006): 9952-7
Su TT, "Cellular responses to DNA damage one signal, multiple choices" Annual review of genetics 40 (2006): 187-208
Stumpff J, Kellogg DR, Krohne KA, Su TT, "Drosophila Wee1 interacts with members of the gammaTURC and is required for proper mitotic-spindle morphogenesis and positioning." Current biology 15 (2005): 1525-34
Garner M, van Kreeveld S, Su TT, "mei-41 and bub1 block mitosis at two distinct steps in response to incomplete DNA replication in Drosophila embryos." Current biology 11 (2001): 1595-9
Click here for the complete list of publications
Garcia K, Duncan T, Su TT, "Analysis of the cell division cycle in Drosophila." Methods (San Diego, Calif.) 41 (2007): 198-205
Wichmann A, Jaklevic B, Su TT, "Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster." Proceedings of the National Academy of Sciences of the United States of America 103 (2006): 9952-7
Su TT, "Cellular responses to DNA damage one signal, multiple choices" Annual review of genetics 40 (2006): 187-208
Stumpff J, Kellogg DR, Krohne KA, Su TT, "Drosophila Wee1 interacts with members of the gammaTURC and is required for proper mitotic-spindle morphogenesis and positioning." Current biology 15 (2005): 1525-34
Garner M, van Kreeveld S, Su TT, "mei-41 and bub1 block mitosis at two distinct steps in response to incomplete DNA replication in Drosophila embryos." Current biology 11 (2001): 1595-9
