Larry Gold - Professor
SELEX / aptamers.
SELEX (Systematic Evolution of Ligands by Exponential enrichment) is a combinatorial chemistry methodology in which vast numbers of oligonucleotides (DNA, RNA, or unnatural compounds) are screened rapidly for specific sequences that have appropriate binding affinities and specificities toward any target. SELEX also has been used to identify new ribozymes and deoxyribozymes.
MCDB
During his prestigious career, Dr. Gold has received many citations including the CU Distinguished Lectureship Award, the National Institutes of Health Merit Award, the Career Development Award, and the Chiron Prize for Biotechnology. In addition, Dr. Gold has been a member of the American Academy of Arts and Sciences since 1993 and the National Academy of Sciences since 1995.
Gander TR, Brody EN, Mehler RE, Heilig JS, Singer BS, Gold L, "Driving forces in cancer diagnostics." MLO: medical laboratory observer 35 (2003): 10-6, 20; quiz 20-1
Brody EN, Gold L, "Aptamers as therapeutic and diagnostic agents." Journal of biotechnology 74 (2000): 5-13
Allen P, Collins B, Brown D, Hostomsky Z, Gold L, "A specific RNA structural motif mediates high affinity binding by the HIV-1 nucleocapsid protein (NCp7)." Virology 225 (1996): 306-15
Beutel BA, Gold L, "In vitro evolution of intrinsically bent DNA." Journal of molecular biology 228 (1992): 803-12
Winter RB, Morrissey L, Gauss P, Gold L, Hsu T, Karam J, "Bacteriophage T4 regA protein binds to mRNAs and prevents translation initiation." Proceedings of the National Academy of Sciences of the United States of America 84 (1987): 7822-6
Click here for the complete list of publications
Brody EN, Gold L, "Aptamers as therapeutic and diagnostic agents." Journal of biotechnology 74 (2000): 5-13
Allen P, Collins B, Brown D, Hostomsky Z, Gold L, "A specific RNA structural motif mediates high affinity binding by the HIV-1 nucleocapsid protein (NCp7)." Virology 225 (1996): 306-15
Beutel BA, Gold L, "In vitro evolution of intrinsically bent DNA." Journal of molecular biology 228 (1992): 803-12
Winter RB, Morrissey L, Gauss P, Gold L, Hsu T, Karam J, "Bacteriophage T4 regA protein binds to mRNAs and prevents translation initiation." Proceedings of the National Academy of Sciences of the United States of America 84 (1987): 7822-6
