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Aminoacyl-RNA synthesis catalyzed by an RNA
Aminoacyl-RNA synthesis catalyzed by an RNA.
47
An RNA has been selected that rapidly aminoacylates its 2'(3') terminus when provided with phenylalanyl-adenosine monophosphate. That is, the RNA accelerates the same aminoacyl group transfer catalyzed by protein aminoacyl-transfer RNA synthetases. The best characterized RNA reaction requires both Mg2+ and Ca2+. These results confirm a necessary prediction of the RNA world hypothesis and represent efficient RNA reaction (> or = 10(5) times accelerated) at a carbonyl carbon, exemplifying a little explored type of RNA catalysis.
Illangasekare M, Sanchez G, Nickles T, Yarus M
Science (New York, N.Y.)
1995-02-03 00:00
267
5198
643-7
Acylation,Adenosine Monophosphate,Aminoacylation,Base Sequence,Calcium,Evolution,Glycolates,Magnesium,Molecular Sequence Data,Nucleic Acid Conformation,Phenylalanine,RNA,RNA, Catalytic,Glycolates,RNA, Catalytic,2-naphthoxyacetic acid,Adenosine Monophosphate,Phenylalanine,RNA,phenylalanyl-5'-AMP,Magnesium,Calcium
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309-0347
Science
NIGMS GM30881, NIGMS GM48080
0036-8075
1398
True
7530860
