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A twisted tRNA intermediate sets the threshold for decoding
A twisted tRNA intermediate sets the threshold for decoding.
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Putting together consistent cryo-EM structure, transient kinetic and mutant tRNA suppressor data, it appears that a deformed or waggling aminoacyl-tRNA is the critical transitional structure examined by the ribosome during decoding at the A site. The unusual conformation may be required for effective proofreading of the codon-anticodon complex.
Yarus M, Valle M, Frank J
RNA (New York, N.Y.)
2003-04-01 00:00
9
4
384-5
Escherichia coli,Kinetics,Microscopy, Electron,Mutation,RNA, Bacterial,RNA, Transfer,Ribosomes,RNA, Bacterial,RNA, Transfer
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA yarusstripecoloradoedu
RNA
1355-8382
1391
True
12649490
