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A tiny RNA that catalyzes both aminoacyl-RNA and peptidyl-RNA synthesis
A tiny RNA that catalyzes both aminoacyl-RNA and peptidyl-RNA synthesis.
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A 29-nt RNA catalyst successively forms the aminoacyl ester phe-RNA, and then peptidyl-RNA (phe-phe-RNA), given phenylalanine adenylate (phe-AMP) as substrate. Catalysis of two related reactions at similar rates supports the argument that RNA catalysts would evolve as groups with similar mechanisms. In particular, successive aminoacyl- and peptidyl-RNA synthesis by one RNA suggests that uncoded but RNA-catalyzed peptide synthesis would evolve before the synthesis of coded peptides.
Illangasekare M, Yarus M
RNA (New York, N.Y.)
1999-11-01 00:00
5
11
1482-9
Acylation,Adenosine Monophosphate,Base Sequence,Catalysis,Kinetics,Molecular Sequence Data,Nucleic Acid Conformation,Phenylalanine,RNA,RNA, Catalytic,RNA, Catalytic,Adenosine Monophosphate,Phenylalanine,RNA
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309-0347, USA
RNA
1355-8382
1390
True
10580476
