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To live or die by the sword the regulation of apoptosis by the proteasome
To live or die by the sword: the regulation of apoptosis by the proteasome.
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The proteasome has been implicated in the control of apoptosis by modulating the levels of both pro- and antiapoptotic molecules. A recent study published in the April 9th issue of Molecular Cell reveals that caspase-dependent inactivation of the proteasome can amplify the activation of apoptosis.
Friedman J, Xue D
Developmental cell
2004-04-01 00:00
6
4
460-1
Apoptosis,Caspases,Cysteine Endopeptidases,Multienzyme Complexes,Peptide Hydrolases,Proteasome Endopeptidase Complex,Signal Transduction,Ubiquitin,Multienzyme Complexes,Ubiquitin,Peptide Hydrolases,Caspases,Cysteine Endopeptidases,Proteasome Endopeptidase Complex
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Dev. Cell
1534-5807
S1534580704001042
1382
True
15068786
