Document Actions
Regulation of mitochondrial membrane per ... -2 family proteins and caspases
Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases.
46
Mitochondria play an important role in the integration and transmission of cell death signals, activating caspases and other cell death execution events by releasing apoptogenic proteins from the intermembrane space. The BCL-2 family of proteins localize (or can be targeted) to mitochondria and regulate the permeability of the mitochondrial outer membrane to these apoptotic factors. Recent evidence suggests that multiple mechanisms may regulate the release of mitochondrial factors, some of which depend on the action of caspases.
Breckenridge DG, Xue D
Current opinion in cell biology
2004-12-01 00:00
16
6
647-52
Animals,Apoptosis,Caspases,Enzyme Activation,Humans,Intracellular Membranes,Membrane Potentials,Mitochondria,Proto-Oncogene Proteins c-bcl-2,Proto-Oncogene Proteins c-bcl-2,Caspases
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Curr. Opin. Cell Biol.
0955-0674
10.1016/j.ceb.2004.09.009
S0955-0674(04)00145-0
1375
True
15530776
