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cdh-3, a gene encoding a member of the c ... nesis in Caenorhabditis elegans
cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans.
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Several genes that encode members of the cadherin superfamily have been identified in Caenorhabditis elegans. Based on the roles of cadherins in vertebrates and Drosophila, it is expected that they function in the control of epithelial morphogenesis, an event which is poorly understood at the molecular level in C. elegans. Reporter genes under the control of upstream sequences from one of these genes, cdh-3, are expressed in developing epithelial cells, but also in a number of neuroectodermal cells that extend processes along some of these epithelial cells. We generated a loss-of-function mutation in cdh-3 by transposon-mediated deletion mutagenesis. This mutation affects the morphogenesis of a single cell, hyp10, which forms the tip of the nematode tail. The lack of detectable defects associated with the other cells expressing cdh-3 reporter constructs hints at the existence of other genes that can compensate for cdh-3 loss of function.
Pettitt J, Wood WB, Plasterk RH
Development (Cambridge, England)
1996-12-01 00:00
122
12
4149-57
Alleles,Amino Acid Sequence,Animals,Base Sequence,Cadherins,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Ectoderm,Epithelium,Female,Genes, Helminth,Genes, Reporter,Genitalia, Female,Male,Molecular Sequence Data,Morphogenesis,Mutagenesis, Insertional,Sequence Analysis, DNA,Sequence Deletion,Sequence Homology, Amino Acid,Tissue Distribution,Transgenes,CDH-3 protein, C elegans,Cadherins,Caenorhabditis elegans Proteins
Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
Development
NICHD HD-14958, NICHD HD-29397, NCRR R01 RR10082-02
0950-1991
1353
True
9012534
