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The tra-1 gene determines sexual phenotype cell-autonomously in C elegans
The tra-1 gene determines sexual phenotype cell-autonomously in C. elegans.
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The tra-1 gene plays a central role in C. elegans sex determination. XX animals develop as hermaphrodites when tra-1 is active and as males when it is not. By analyzing a large number of tra-1 genetic mosaics we have shown that, with the expected exception of vulval induction by the hermaphrodite gonad, tra-1 functions cell-autonomously, consistent with a role as an intracellular component of a signaling pathway. Moreover, all the sexual differentiation genes under tra-1 control must also function cell-autonomously. Our results have additional implications for several aspects of postembryonic development, including mechanisms of sex-specific directed cell migrations and the question of an organizer in the male tail.
Hunter CP, Wood WB
Cell
1990-12-21 00:00
63
6
1193-204
Animals,Caenorhabditis,Clone Cells,Female,Genes,Hermaphroditism,Intestines,Male,Models, Genetic,Mosaicism,Phenotype,RNA, Messenger,Sex Determination (Analysis),Vitellogenins,RNA, Messenger,Vitellogenins
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309
Cell
NICHD HD-11762
0092-8674
0092-8674(90)90415-B
1350
True
2261640
