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PGL-1, a predicted RNA-binding component ... tial for fertility in C elegans
PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans.
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Germ cells are distinct from somatic cells in their immortality, totipotency, and ability to undergo meiosis. Candidates for components that guide the unique germline program are the distinctive granules observed in germ cells of many species. We show that a component of germ granules is essential for fertility in C. elegans and that its primary function is in germline proliferation. This role has been revealed by molecular and genetic analyses of pgl-1. PGL-1 is a predicted RNA-binding protein that is present on germ granules at all stages of development. Elimination of PGL-1 results in defective germ granules and sterility. Interestingly, PGL-1 function is required for fertility only at elevated temperatures, suggesting that germline development is inherently sensitive to temperature.
Kawasaki I, Shim YH, Kirchner J, Kaminker J, Wood WB, Strome S
Cell
1998-09-04 00:00
94
5
635-45
Alleles,Amino Acid Sequence,Animals,Base Sequence,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Cloning, Molecular,Cytoplasmic Granules,Epitopes,Female,Fertility,Germ Cells,Helminth Proteins,Infertility,Molecular Sequence Data,Mutation,RNA-Binding Proteins,Sequence Alignment,Temperature,Transcription, Genetic,Zygote,Caenorhabditis elegans Proteins,Epitopes,Helminth Proteins,PGL-1 protein, C elegans,RNA-Binding Proteins
Department of Biology, Indiana University, Bloomington 47405, USA
Cell
NIGMS GM34059
0092-8674
S0092-8674(00)81605-0
1341
True
9741628
