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Molecular characterization of the her-1 ... ditis elegans sex determination
Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination.
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We have characterized two transcripts from the male-determining her-1 locus in Caenorhabditis elegans. The larger transcript, which appears more important for male development, is predicted to encode a novel 175-amino-acid, cysteine-rich polypeptide with an apparent amino-terminal signal sequence and potential cleavage and glycosylation sites. Expression of a full-length cDNA construct for the larger transcript driven by a body-wall-myosin promoter causes extensive masculinization of all sexually dimorphic tissues in XX (normally hermaphrodite) animals. This activity is dependent on the presence of the her-1 signal sequence or a substitute synthetic signal sequence in the encoded polypeptide. These results suggest that a secreted product of the her-1 gene dictates male development.
Perry MD, Li W, Trent C, Robertson B, Fire A, Hageman JM, Wood WB
Genes & development
1993-02-01 00:00
7
2
216-28
Amino Acid Sequence,Animals,Base Sequence,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Helminth Proteins,Molecular Sequence Data,Promoter Regions (Genetics),Protein Sorting Signals,Sex Differentiation,Signal Transduction,Caenorhabditis elegans Proteins,Helminth Proteins,Protein Sorting Signals,her-1 protein, C elegans
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309-0347
Genes Dev.
NIGMS GM-37706, NIGMS GM-43333, NICHD HD-11762
0890-9369
1337
True
8436294
