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Genetic analysis of life-span in Caenorhabditis elegans
Genetic analysis of life-span in Caenorhabditis elegans.
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Crosses between Bristol and Bergerac strains of the self-fertilizing hermaphroditic nematode Caenorhabditis elegans do not show the heterosis effects for life-span that complicate analysis of interstrain crosses with Drosophila or mice. Instead they yield F1 progeny with life-spans similar to those of the parent strains. By analysis of life-span variation among progeny F2 populations from such crosses and by two independent analyses of life-spans among recombinant inbred lines derived from F2 individuals by 18 rounds of self-fertilization, we estimate that the heritability of life-span in C. elegans is between 20% and 50%. Recombinant inbred lines show a range in mean life-spans of 10 days to 31 days compared to life-spans of about 18 days for each of the two parental strains. We conclude that life-span variation in C. elegans has a substantial genetic component and that this organism offers promising opportunities for selective breeding of longer-lived strains and genetic analysis of senescence.
Johnson TE, Wood WB
Proceedings of the National Academy of Sciences of the United States of America
1982-11-01 00:00
79
21
6603-7
Aging,Animals,Caenorhabditis,Hybridization, Genetic
Proc. Natl. Acad. Sci. U.S.A.
NIA AG-01236, NICHD HD-11762
0027-8424
1327
True
6959141
