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Extragenic suppressors of a dominant mas ... determination in different ways
Extragenic suppressors of a dominant masculinizing her-1 mutation in C. elegans identify two new genes that affect sex determination in different ways.
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Summary: The her-1 regulatory switch gene in C. elegans sex determination is normally active in XO animals, resulting in male development, and inactive in XX animals, allowing hermaphrodite development. The her-1(n695gf) mutation results in the incomplete transformation of XX animals into phenotypic males. We describe four extragenic mutations that suppress the masculinized phenotype of her-1(n695gf) XX. They define two previously undescribed genes, sup-26 and sup-27. All four mutations exhibit semidominance of suppression and by themselves have no visible effects on sex determination in otherwise genotypically wild-type XX or XO animals. Analysis of interactions with mutations in the major sex-determining genes show that sup-26 and sup-27 influence sex determination in fundamentally different ways. sup-26 appears to act independently of her-1 to negatively modulate synthesis or function of tra-2 in both XX and XO animals. sup-27 may play a role in X-chromosome dosage compensation and influence sex determination indirectly.
Manser J, Wood WB, Perry MD
Genesis (New York, N.Y. : 2000)
2002-11-01 00:00
34
3
184-95
Animals,Caenorhabditis elegans,Caenorhabditis elegans Proteins,DNA-Binding Proteins,Dosage Compensation, Genetic,Genes, Suppressor,Helminth Proteins,Membrane Proteins,Mutation,Sex Determination (Genetics),Transcription Factors,X Chromosome,Caenorhabditis elegans Proteins,DNA-Binding Proteins,Helminth Proteins,Membrane Proteins,Sdc-3 protein, C elegans,Transcription Factors,her-1 protein, C elegans,tra-1 protein, C elegans,tra-2 protein, C elegans
Department of MCD Biology, University of Colorado, Boulder, Colorado, USA
Genesis
1526-954X
10.1002/gene.10118
1322
True
12395383
