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Expression of the C elegans labial ortho ... during male tail morphogenesis
Expression of the C. elegans labial orthologue ceh-13 during male tail morphogenesis.
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Hox genes are transcriptional regulators of metazoan body regionalization along the anteroposterior axis that act by specifying positional identity in differentiating cells. ceh-13, the labial orthologue in Caenorhabditis elegans, is expressed both during embryogenesis and post- embryonic development. Using GFP reporter analysis and immunocytochemistry, we discovered a spatiotemporal pattern of gene expression in the male tail during the L3 and L4 larval stages that is TGF-beta pathway-dependent. Analysis of reporter activity in transgenic animals identified a distinct promoter region driving male tail-specific ceh-13 expression. We also report the interspecies conservation of sequence motifs within this region and speculate that, in the course of evolutionary diversification, ceh-13 may have acquired new functionality while conserving its homeotic role.
Stoyanov CN, Fleischmann M, Suzuki Y, Tapparel N, Gautron F, Streit A, Wood WB, Müller F
Developmental biology
2003-07-01 00:00
259
1
137-49
Animals,Base Sequence,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Conserved Sequence,Enhancer Elements (Genetics),Homeodomain Proteins,Male,Molecular Sequence Data,Morphogenesis,Neuropeptides,Promoter Regions (Genetics),Rectum,Tail,Transforming Growth Factor beta,CEH-13 protein, C elegans,Caenorhabditis elegans Proteins,Dbl-1 protein, C elegans,Homeodomain Proteins,Neuropeptides,Transforming Growth Factor beta
Institute of Zoology, University of Fribourg, Prolles, 1700 Fribourg, Switzerland
Dev. Biol.
NICHD HD-14958
0012-1606
S0012160603001386
1321
True
12812794
