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An autosomal gene that affects X chromos ... ation in Caenorhabditis elegans
An autosomal gene that affects X chromosome expression and sex determination in Caenorhabditis elegans.
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Recessive mutant alleles at the autosomal dpy-21 locus of C. elegans cause a dumpy phenotype in XX animals but not in XO animals. This dumpy phenotype is characteristic of X chromosome aneuploids with higher than normal X to autosome ratios and is proposed to result from overexpression of X-linked genes. We have isolated a new dpy-21 allele that also causes partial hermaphroditization of XO males, without causing the dumpy phenotype. All dpy-21 alleles show hermaphroditization effects in XO males that carry a duplication of part of the X chromosome and also partially suppress a transformer (tra-1) mutation that converts XX animals into males. Experiments with a set of X chromosome duplications show that the defects of dpy-21 mutants can result from interaction with several different regions of the X chromosome. We propose that dpy-21 regulates X chromosome expression and may be involved in interpreting X chromosome dose for the developmental decisions of both sex determination and dosage compensation.
Meneely PM, Wood WB
Genetics
1984-01-01 00:00
106
1
29-44
Alleles,Animals,Caenorhabditis,Dosage Compensation, Genetic,Female,Gene Expression Regulation,Phenotype,Sex Determination (Analysis),X Chromosome
Genetics
NIGMS GM-07775, NICHD HD-11762, NIA N01-AG-9-2113
0016-6731
1306
True
6537930
