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A novel dominant transformer allele of t ... her-1 of Caenorhabditis elegans
A novel dominant transformer allele of the sex-determining gene her-1 of Caenorhabditis elegans.
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We have characterized a novel dominant allele of the sex-determining gene her-1 of Caenorhabditis elegans. This allele, called n695, results in the incomplete transformation of XX animals into phenotypic males. Previously characterized recessive her-1 alleles transform XO animals into phenotypic hermaphrodites. We have identified five new recessive her-1 mutations as intragenic suppressors of n695. Three of these suppressors are weak, temperature-sensitive alleles. We show that the recessive her-1 mutations are loss-of-function alleles, and that the her-1(n695) mutation results in a gain-of-function at the her-1 locus. The existence of dominant and recessive alleles that cause opposite phenotypic transformations demonstrates that the her-1 gene acts to control sexual identity in C. elegans.
Trent C, Wood WB, Horvitz HR
Genetics
1988-09-01 00:00
120
1
145-57
Alleles,Animals,Caenorhabditis,Female,Genes, Dominant,Genes, Recessive,Hermaphroditism,Male,Mutation,Sex Determination (Analysis),Suppression, Genetic
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Genetics
NIGMS GM22663, NIGMS GM244943, NICHD HD11762
0016-6731
1302
True
3220248
