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A BMP homolog acts as a dose-dependent r ... rning in Caenorhabditis elegans
A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans.
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We cloned the dbl-1 gene, a C. elegans homolog of Drosophila decapentaplegic and vertebrate BMP genes. Loss-of-function mutations in dbl-1 cause markedly reduced body size and defective male copulatory structures. Conversely, dbl-1 overexpression causes markedly increased body size and partly complementary male tail phenotypes, indicating that DBL-1 acts as a dose-dependent regulator of these processes. Evidence from genetic interactions indicates that these effects are mediated by a Smad signaling pathway, for which DBL-1 is a previously unidentified ligand. Our study of the dbl-1 expression pattern suggests a role for neuronal cells in global size regulation as well as male tail patterning.
Suzuki Y, Yandell MD, Roy PJ, Krishna S, Savage-Dunn C, Ross RM, Padgett RW, Wood WB
Development (Cambridge, England)
1999-01-01 00:00
126
2
241-50
Amino Acid Sequence,Animals,Base Sequence,Body Constitution,Body Patterning,Bone Morphogenetic Proteins,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Cloning, Molecular,Epistasis, Genetic,Gene Expression Regulation, Developmental,Genes, Reporter,Genitalia,Hermaphroditism,Male,Molecular Sequence Data,Mutation,Neurons,Neuropeptides,Phenotype,Phylogeny,RNA, Messenger,Sequence Analysis, DNA,Sequence Homology, Amino Acid,Tail,Transforming Growth Factor beta,Bone Morphogenetic Proteins,Caenorhabditis elegans Proteins,Dbl-1 protein, C elegans,Neuropeptides,RNA, Messenger,Transforming Growth Factor beta
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309-0347, USA woodstripe coloradoedu
Development
0950-1991
1300
True
9847238
