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Mechanisms of genetic instability reveal ... t spindle pole body duplication
Mechanisms of genetic instability revealed by analysis of yeast spindle pole body duplication.
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Aneuploidy and polyploidy are commonly observed in transformed cells. These states arise from failures during mitotic chromosome segregation, some of which can be traced to defects in the function or duplication of the centrosome. The centrosome is the organizing center for the mitotic spindle, and the equivalent organelle in the budding yeast, Saccharomyces cerevisiae, is the spindle pole body. We review how defects in spindle pole body duplication or function lead to genetic instability in yeast. There are several well documented instances of genetic instability in yeast that can be traced to the spindle pole body, all of which serve as models for genetic instability in transformed cells.
Chial HJ, Winey M
Biology of the cell / under the auspices of the European Cell Biology Organization
1999-07-01 00:00
91
6
439-50
Aneuploidy,Mitotic Spindle Apparatus,Saccharomyces cerevisiae
University of Colorado-Boulder 80309-0347, USA
Biol. Cell
0248-4900
S0248-4900(99)80085-9
1259
True
10519004
