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Centrosomes and tumour suppressors
Centrosomes and tumour suppressors.
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Centrosomes are microtubule organising centres that act as spindle poles during mitosis. Recent work implicates centrosomes in many other processes, and shows that centrosome defects can cause genetic instability. Many regulators of mammalian centrosome function were predicted from studies of model systems. Surprisingly, some well-known tumour suppressors have recently been found at centrosomes, where they influence centrosome duplication and function, suggesting that control of centrosome function is central to genetic stability.
Fisk HA, Mattison CP, Winey M
Current opinion in cell biology
2002-12-01 00:00
14
6
700-5
Animals,Centrosome,Models, Biological,Mutation,Tumor Suppressor Proteins,Tumor Suppressor Proteins
Molecular, Cellular and Developmental Biology, UCB347, University of Colorado, Boulder, CO 80309-0347, USA
Curr. Opin. Cell Biol.
NIGMS GM 54942, NIGMS GM51312
0955-0674
S095506740200385X
1243
True
12473342
