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Cdc53p acts in concert with Cdc4p and Cd ... a conserved family of proteins
Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins.
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Regulation of cell cycle progression occurs in part through the targeted degradation of both activating and inhibitory subunits of the cyclin-dependent kinases. During G1, CDC4, encoding a WD-40 repeat protein, and CDC34, encoding a ubiquitin-conjugating enzyme, are involved in the destruction of these regulators. Here we describe evidence indicating that CDC53 also is involved in this process. Mutations in CDC53 cause a phenotype indistinguishable from those of cdc4 and cdc34 mutations, numerous genetic interactions are seen between these genes, and the encoded proteins are found physically associated in vivo. Cdc53p defines a large family of proteins found in yeasts, nematodes, and humans whose molecular functions are uncharacterized. These results suggest a role for this family of proteins in regulating cell cycle proliferation through protein degradation.
Mathias N, Johnson SL, Winey M, Adams AE, Goetsch L, Pringle JR, Byers B, Goebl MG
Molecular and cellular biology
1996-12-01 00:00
16
12
6634-43
Amino Acid Sequence,Base Sequence,CDC2 Protein Kinase,Cell Cycle,Cell Cycle Proteins,F-Box Proteins,G1 Phase,Gene Expression Regulation,Molecular Sequence Data,Mutation,S Phase,Saccharomyces cerevisiae,Saccharomyces cerevisiae Proteins,Sequence Alignment,Tumor Suppressor Protein p53,Ubiquitin-Protein Ligases,CDC4 protein, S cerevisiae,Cell Cycle Proteins,F-Box Proteins,Saccharomyces cerevisiae Proteins,Tumor Suppressor Protein p53,CDC2 Protein Kinase,Ubiquitin-Protein Ligases
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202-5122, USA
Mol. Cell. Biol.
NIGMS GM18541, NIGMS GM31006, NIGMS GM45460
0270-7306
1238
True
8943317
