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Evolution of the sperm aster after micro ... eiotically mature human oocytes
Evolution of the sperm aster after microinjection of isolated human sperm centrosomes into meiotically mature human oocytes.
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This study examined the feasibility of isolating and transferring the centrosome-containing region of spermatozoa to mature human oocytes. The findings demonstrate that individual sperm centrosomes can be transferred and are capable of nucleating maternal tubulin to form a well-developed sperm aster in the recipient oocyte. The results are discussed with respect to centrosome function in early human development and applications in clinical in-vitro fertilization in the treatment of certain forms of male factor infertility.
Van Blerkom J, Davis P
Human reproduction (Oxford, England)
1995-08-01 00:00
10
8
2179-82
Cell Aging,Cell Fractionation,Centrosome,Feasibility Studies,Female,Fluorescent Antibody Technique,Humans,Male,Meiosis,Microinjections,Microtubules,Oocytes,Sperm-Ovum Interactions,Spermatozoa,Tubulin,Tubulin
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309, USA
Hum. Reprod.
NICHD HD 31907
0268-1161
1188
True
8567869
