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Macromolecular structure determination b ... new advances and recent results
Macromolecular structure determination by electron microscopy: new advances and recent results.
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Electron microscopy is undergoing a mini-renaissance, as a number of biological systems are yielding to higher resolution analysis as a result of advances in instrumentation, specimen preparation and image-processing technology. The atomic structure of tubulin has now been solved, crucial elements of secondary structure have recently been revealed in several membrane proteins (rhodopsin, gap junctions, aquaporin, and Ca2+ and H+ ATPases) and in a virus particle, and macromolecular complexes are being seen in increasingly fine detail. This growth has been enhanced further by the ability to combine structures of macromolecular complexes derived by electron microscopy with X-ray structures of their components, in order to reconstruct molecular machines and large multiprotein complexes in immense detail.
Stowell MH, Miyazawa A, Unwin N
Current opinion in structural biology
1998-10-01 00:00
8
5
595-600
Crystallization,Crystallography, X-Ray,Microscopy, Electron,Proteins,Proteins
MRC Laboratory of Molecular Biology, Cambridge, UK
Curr. Opin. Struct. Biol.
0959-440X
1106
True
9818263
