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Building specificity with nonspecific RNA-binding proteins
Building specificity with nonspecific RNA-binding proteins.
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<p>Specificity is key to biological regulation. Two families of RNA binding proteins, heterogeneous nuclear ribonucleoproteins and serine-arginine-rich proteins, were initially thought to have redundant or nonspecific biochemical functions. Recently, members of these families have been found as components of distinct regulatory complexes with highly specific and essential roles in mRNA metabolism. Here we discuss the basis for their functional specificity and the mechanisms of action of some of their characteristic protein domains.</p>
Singh R, Valcárcel J
Nature structural & molecular biology
2005-08-01 00:00
12
8
645-53
Amino Acids,Gene Expression Regulation,Models, Molecular,Protein Structure, Tertiary,RNA Splicing,RNA, Messenger,RNA-Binding Proteins,Ribonucleoproteins,Substrate Specificity,Amino Acids,RNA, Messenger,RNA-Binding Proteins,Ribonucleoproteins,messenger rib
Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309, USA. rsingh@colorado.edu
Nat. Struct. Mol. Biol.
1545-9993
10.1038/nsmb961
nsmb961
0
False
16077728
