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Release of two Saccharomyces cerevisiae ... the SNF1 and SSN6 gene products
Release of two Saccharomyces cerevisiae cytochrome genes, COX6 and CYC1, from glucose repression requires the SNF1 and SSN6 gene products.
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We show here that SNF1 and SSN6 are required for derepression of the glucose-repressible yeast genes COX6 and CYC1, which encode the mitochondrial proteins cytochrome c oxidase subunit VI and iso-1-cytochrome c, respectively. In an snf1 mutant genetic background, the transcription of both COX6 and CYC1 continued to be repressed after cells were shifted into derepressing media. In an ssn6 mutant genetic background, both COX6 and CYC1 were expressed constitutively at high levels in repressing media. SSN6 acted epistatically to SNF1 in the regulation of both cytochrome genes. These findings are similar to previous findings on the effects of SNF1 and SSN6 on SUC2 expression in Saccharomyces cerevisiae and are consistent with a model proposing that SNF1 exerts its effect through SSN6 on COX6 and CYC1.
Wright RM, Poyton RO
Molecular and cellular biology
1990-03-01 00:00
10
3
1297-300
Blotting, Northern,Cytochrome c Group,Cytochromes c,Electron Transport Complex IV,Gene Expression Regulation, Fungal,Genes, Fungal,Glucose,Protein Kinases,RNA, Messenger,Saccharomyces cerevisiae,Saccharomyces cerevisiae Proteins,Transcription, Genetic,CYC1 protein, S cerevisiae,Cytochrome c Group,RNA, Messenger,Saccharomyces cerevisiae Proteins,Glucose,Cytochromes c,Electron Transport Complex IV,Protein Kinases
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347
Mol. Cell. Biol.
NIGMS GM34827
0270-7306
1064
True
2154683
