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Overexpression of a leaderless form of y ... peptide in mitochondrial import
Overexpression of a leaderless form of yeast cytochrome c oxidase subunit Va circumvents the requirement for a leader peptide in mitochondrial import.
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Subunit Va of Saccharomyces cerevisiae cytochrome c oxidase is a nucleus-encoded mitochondrial protein that is derived from a precursor with a 20-residue leader peptide. We previously reported that this leader peptide is required for import of subunit Va into mitochondria in vivo (S. M. Glaser, C. E. Trueblood, L. K. Dircks, R. O. Poyton, and M. G. Cumsky, J. Cell. Biochem. 36:275-278, 1988). Here we show that overproduction of a leaderless form of subunit Va circumvents the leader peptide requirement for import into mitochondria in vivo.
Dircks LK, Poyton RO
Molecular and cellular biology
1990-09-01 00:00
10
9
4984-6
Cell Nucleus,Electron Transport Complex IV,Gene Expression,Genes, Fungal,Genotype,Macromolecular Substances,Mitochondria,Mutation,Plasmids,Protein Sorting Signals,Saccharomyces cerevisiae,Macromolecular Substances,Protein Sorting Signals,Electron Transport Complex IV
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309-0347
Mol. Cell. Biol.
NIGMS GM-30228
0270-7306
1053
True
2167443
