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Differential regulation of the two genes ... eme and the HAP2 and REO1 genes
Differential regulation of the two genes encoding Saccharomyces cerevisiae cytochrome c oxidase subunit V by heme and the HAP2 and REO1 genes.
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In Saccharomyces cerevisiae, the COX5a and COX5b genes encode two forms of cytochrome c oxidase subunit V, Va and Vb. We report here that heme increases COX5a expression and decreases COX5b expression and that the HAP2 and REO1 genes are involved in positive regulation of COX5a and negative regulation of COX5b, respectively. Heme regulation of COX5a and COX5b may dictate which subunit V isoform is available for assembly into cytochrome c oxidase under conditions of high- and low-oxygen tension.
Trueblood CE, Wright RM, Poyton RO
Molecular and cellular biology
1988-10-01 00:00
8
10
4537-40
Blotting, Northern,Electron Transport Complex IV,Gene Expression Regulation,Genes, Fungal,Heme,Oxygen,RNA, Messenger,Saccharomyces cerevisiae,Transcription, Genetic,RNA, Messenger,Heme,Oxygen,Electron Transport Complex IV
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309
Mol. Cell. Biol.
NIGMS GM30228
0270-7306
1027
True
2847035
