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Gold nanoparticles enhanced optical trap ... oupled with significant heating
Gold nanoparticles: enhanced optical trapping and sensitivity coupled with significant heating.
33
Gold nanoparticles appear to be superior handles in optical trapping assays. We demonstrate that relatively large gold particles (R(b)=50 nm) indeed yield a sixfold enhancement in trapping efficiency and detection sensitivity as compared to similar-sized polystyrene particles. However, optical absorption by gold at the most common trapping wavelength (1064 nm) induces dramatic heating (266 degrees C/W). We determined this heating by comparing trap stiffness from three different methods in conjunction with detailed modeling. Due to this heating, gold nanoparticles are not useful for temperature-sensitive optical-trapping experiments, but may serve as local molecular heaters. Also, such particles, with their increased detection sensitivity, make excellent probes for certain zero-force biophysical assays.
Seol Y, Carpenter AE, Perkins TT
Optics letters
2006-08-15 00:00
31
16
2429-31
Energy Transfer,Gold,Heat,Lasers,Micromanipulation,Nanostructures,Reproducibility of Results,Sensitivity and Specificity,Thermography,Gold
JILA, University of Colorado, and National Institute of Standards and Technology, Boulder, CO 80309, USA
NIGMS T32 GM 065103
0146-9592
92492
1001
True
16880845
