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Conventional and molecular epidemiology ... ered from HIV-infected patients
Conventional and molecular epidemiology of macrolide resistance among new Mycobacterium avium complex isolates recovered from HIV-infected patients.
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We performed a retrospective cohort study of human immunodeficiency virus (HIV)-associated Mycobacterium avium complex (MAC) infection during 1997-2004 to assess for factors associated with initial macrolide resistance. Of 52 HIV-associated sterile-site MAC isolates, 9 (17%) were initially macrolide resistant. Prior MAC treatment and prolonged MAC prophylaxis with macrolides were associated with infection with a macrolide-resistant isolate; 2 (22%) of 9 patients had limited or no prior macrolide exposure. Initial MAC isolates in HIV-infected persons should routinely be tested for macrolide resistance.
Gardner EM, Burman WJ, DeGroote MA, Hildred G, Pace NR
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2005-10-01 00:00
41
7
1041-4
Adult,Anti-Bacterial Agents,Cohort Studies,Drug Resistance, Multiple, Bacterial,Epidemiology, Molecular,Female,HIV Infections,Humans,Macrolides,Male,Middle Aged,Mycobacterium avium Complex,Mycobacterium avium-intracellulare Infection,Retrospective Studies,Anti-Bacterial Agents,Macrolides
Denver Public Health, Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80204, USA
Clin. Infect. Dis.
NIAID 2 T32 AI07447-11
1537-6591
10.1086/433187
CID36570
913
True
16142672
