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Bacterial RNase P a new view of an ancient enzyme
Bacterial RNase P: a new view of an ancient enzyme.
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Ribonuclease P (RNase P) is a ubiquitous endonuclease that catalyses the maturation of the 5' end of transfer RNA (tRNA). Although it carries out a biochemically simple reaction, RNase P is a complex ribonucleoprotein particle composed of a single large RNA and at least one protein component. In bacteria and some archaea, the RNA component of RNase P can catalyse tRNA maturation in vitro in the absence of proteins. The discovery of the catalytic activity of the bacterial RNase P RNA triggered numerous mechanistic and biochemical studies of the reactions catalysed by the RNA alone and by the holoenzyme and, in recent years, structures of individual components of the RNase P holoenzyme have been determined. The goal of the present review is to summarize what is known about the bacterial RNase P, and to bring together the recent structural results with extensive earlier biochemical and phylogenetic findings.
Kazantsev AV, Pace NR
Nature reviews. Microbiology
2006-10-01 00:00
4
10
729-40
Bacteria,Catalysis,Phylogeny,RNA, Transfer,Ribonuclease P,Substrate Specificity,RNA, Transfer,Ribonuclease P
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA
Nat. Rev. Microbiol.
1740-1534
10.1038/nrmicro1491
nrmicro1491
899
True
16980936
