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Sonic hedgehog inhibits the terminal dif ... tted to the slow muscle lineage
Sonic hedgehog inhibits the terminal differentiation of limb myoblasts committed to the slow muscle lineage.
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The proliferation, differentiation, and fusion of a small number of myogenic precursor cells must be precisely regulated during development to ensure the proper size, organization, and function of the limb musculature. We have examined the role of Sonic hedgehog (Shh) in these processes by both augmentation and inhibition of the Shh-mediated signaling pathway. Our data show that Shh regulates muscle development by repressing the terminal differentiation of early myogenic precursor cells and does not function as a myoblast mitogen. Shh function in hypaxial muscle appears to be spatially restricted to the early myoblast population within the ventral muscles of the posterior region of the limb. Furthermore, Shh appears to act as a permissive, rather than an inductive, signal for slow MyHC expression in myoblasts. Our data thus provide the foundation for a new hypothesis for Shh function in hypaxial skeletal muscle development.
Bren-Mattison Y, Olwin BB
Developmental biology
2002-02-15 00:00
242
2
130-48
Animals,Base Sequence,Cell Differentiation,Cells, Cultured,Chick Embryo,DNA Primers,Hedgehog Proteins,Hindlimb,Immunohistochemistry,Muscle, Skeletal,Trans-Activators,DNA Primers,Hedgehog Proteins,Trans-Activators
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Dev. Biol.
NIAMS AR39467, NIGMS GM07135
0012-1606
10.1006/dbio.2001.0528
S0012160601905287
893
True
11820811
