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Requirement of heparan sulfate for bFGF- ... th and myoblast differentiation
Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation.
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Basic fibroblast growth factor (bFGF) binds to heparan sulfate proteoglycans at the cell surface and to receptors with tyrosine kinase activity. Prevention of binding between cell surface heparan sulfate and bFGF (i) substantially reduces binding of fibroblast growth factor to its cell-surface receptors, (ii) blocks the ability of bFGF to support the growth of Swiss 3T3 fibroblasts, and (iii) induces terminal differentiation of MM14 skeletal muscle cells, which is normally repressed by fibroblast growth factor. These results indicate that cell surface heparan sulfate is directly involved in bFGF cell signaling.
Rapraeger AC, Krufka A, Olwin BB
Science (New York, N.Y.)
1991-06-21 00:00
252
5013
1705-8
Animals,Cell Differentiation,Cell Division,Cell Line,Chlorates,Fibroblast Growth Factor 2,Fibroblasts,Heparitin Sulfate,Mice,Muscles,Polysaccharide-Lyases,Protein Binding,Receptors, Cell Surface,Structure-Activity Relationship,Chlorates,Receptors, Cell Surface,Fibroblast Growth Factor 2,sodium chlorate,Heparitin Sulfate,Polysaccharide-Lyases,heparitinsulfate lyase
Department of Pathology, University of Wisconsin, Madison 53706
Science
PHS 5T32H007118, NIAMS AR39467, NICHD HD21881
0036-8075
890
True
1646484
