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Identification of a fibroblast growth fa ... tein in Drosophila melanogaster
Identification of a fibroblast growth factor-binding protein in Drosophila melanogaster.
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As assessed by competitive binding and protein-crosslinking experiments, Drosophila melanogaster cells possess basic fibroblast growth factor (bFGF)-specific binding proteins that are similar to FGF receptors on vertebrate cells in molecular weight and binding affinity; these D. melanogaster cells, however, have no detectable binding proteins for acidic fibroblast growth factor (aFGF). Consistent with the presence of bFGF-specific binding proteins, D. melanogaster cells degrade bFGF but not aFGF. These results indicate the conservation of heparin-binding growth factors and receptors between vertebrates and D. melanogaster.
Doctor JS, Hoffmann FM, Olwin BB
Molecular and cellular biology
1991-04-01 00:00
11
4
2319-23
Animals,Binding, Competitive,Drosophila melanogaster,Fibroblast Growth Factors,Molecular Weight,Receptors, Cell Surface,Receptors, Fibroblast Growth Factor,Receptors, Cell Surface,Receptors, Fibroblast Growth Factor,Fibroblast Growth Factors
McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, Madison 53706
Mol. Cell. Biol.
NIAMS AR39467, NCI CA07175
0270-7306
875
True
1848676
