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FGF-2 apical ectodermal ridge growth signal for chick limb development
FGF-2: apical ectodermal ridge growth signal for chick limb development.
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The apical ectodermal ridge permits growth and elongation of amniote limb buds; removal causes rapid changes in mesodermal gene expression, patterned cell death, and truncation of the limb. Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development. A bioassay for FGFs demonstrated that FGF-2 was the only detectable FGF in chick limb bud extracts. By distribution and bioactivity, FGF-2 is the prime candidate for the chick limb bud apical ridge growth signal.
Fallon JF, López A, Ros MA, Savage MP, Olwin BB, Simandl BK
Science (New York, N.Y.)
1994-04-01 00:00
264
5155
104-7
Animals,Biological Assay,Cell Death,Cell Differentiation,Cell Line,Cell Survival,Chick Embryo,DNA-Binding Proteins,Ectoderm,Extremities,Fibroblast Growth Factors,Gene Expression,Genes, Homeobox,Homeodomain Proteins,Humans,MSX1 Transcription Factor,Mesoderm,Muscles,Recombinant Proteins,Transcription Factors,DNA-Binding Proteins,Homeodomain Proteins,MSX1 Transcription Factor,Recombinant Proteins,Transcription Factors,Fibroblast Growth Factors
Anatomy Department, University of Wisconsin, Madison 53706
Science
NIGMS 5T32GM07507, NICHD HD20743
0036-8075
867
True
7908145
