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Essential and separable roles for Syndec ... le development and regeneration
Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration.
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Syndecan-3 and syndecan-4 function as coreceptors for tyrosine kinases and in cell adhesion. Syndecan-3(-/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells. Explanted syndecan-3(-/-) satellite cells mislocalize MyoD, differentiate aberrantly, and exhibit a general increase in overall tyrosine phosphorylation. Following induced regeneration, the hyperplastic phenotype is recapitulated. While there are fewer apparent defects in syndecan-4(-/-) muscle, explanted satellite cells are deficient in activation, proliferation, MyoD expression, myotube fusion, and differentiation. Further, syndecan-4(-/-) satellite cells fail to reconstitute damaged muscle, suggesting a unique requirement for syndecan-4 in satellite cell function.
Cornelison DD, Wilcox-Adelman SA, Goetinck PF, Rauvala H, Rapraeger AC, Olwin BB
Genes & development
2004-09-15 00:00
18
18
2231-6
Animals,Cell Division,Cells, Cultured,Female,Gene Expression Regulation, Developmental,Membrane Glycoproteins,Mice,Mice, Mutant Strains,Muscle Development,Muscle Fibers,Muscle, Skeletal,Muscular Dystrophies,MyoD Protein,Proteoglycans,Regeneration,Satellite Cells, Skeletal Muscle,Syndecan-3,Syndecan-4,Membrane Glycoproteins,MyoD Protein,Proteoglycans,Sdc3 protein, mouse,Sdc4 protein, mouse,Syndecan-3,Syndecan-4
Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309, USA
Genes Dev.
NIAMS AR39467, NIGMS GM48850, NICHD HD21881, NICHD HD37490, NIAMS R01 AR039467-17
0890-9369
10.1101/gad.1214204
18/18/2231
866
True
15371336
