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Receptor downregulation and multivesicular-body sorting
Receptor downregulation and multivesicular-body sorting.
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The sorting of proteins into the inner vesicles of multivesicular bodies is required for many key cellular processes, which range from the downregulation of activated signalling receptors to the proper stimulation of the immune response. Recent advances in our understanding of the multivesicular-body sorting pathway have resulted from the identification of ubiquitin as a signal for the efficient sorting of proteins into this transport route, and from the discovery of components of the sorting and regulatory machinery that directs this complex process.
Katzmann DJ, Odorizzi G, Emr SD
Nature reviews. Molecular cell biology
2002-12-01 00:00
3
12
893-905
Animals,Carrier Proteins,Cytoplasmic Vesicles,Down-Regulation,Endosomes,Epidermal Growth Factor,Humans,Membrane Proteins,Models, Biological,Phospholipids,Protein Structure, Tertiary,Protein Transport,Receptors, Cell Surface,Receptors, Notch,Saccharomyces cerevisiae Proteins,Signal Transduction,Ubiquitin,Vesicular Transport Proteins,Yeasts,Carrier Proteins,Membrane Proteins,Phospholipids,Receptors, Cell Surface,Receptors, Notch,STP22 protein, S cerevisiae,Saccharomyces cerevisiae Proteins,Ubiquitin,Vesicular Transport Proteins,Epidermal Growth Factor
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA katzmanndavidmayoedu
Nat. Rev. Mol. Cell Biol.
1471-0072
10.1038/nrm973
nrm973
842
True
12461556
