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Molecular mechanisms of late endosome morphology, identity and sorting
Molecular mechanisms of late endosome morphology, identity and sorting.
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Recent studies using electron microscopy, protein crystallography, classic biochemistry and novel live-cell imaging have provided numerous insights into the endocytic pathway, describing a dynamic system in which compartment morphology, molecular identity and the mechanics of cargo sorting are intimately connected. Current evidence supports a model of maturation in which the lipids, cargo proteins and Rab population at the endosome determine its competence to perform the functions of late endosomes, including the sorting of cargoes into lumenal vesicles and fusion with lysosomes.
Russell MR, Nickerson DP, Odorizzi G
Current opinion in cell biology
2006-08-01 00:00
18
4
422-8
Animals,Carrier Proteins,Endosomes,Humans,Lysosomes,Models, Biological,Transport Vesicles,Carrier Proteins
Molecular, Cellular, and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309-0347, USA
Curr. Opin. Cell Biol.
NIGMS GM07135
0955-0674
10.1016/j.ceb.2006.06.002
S0955-0674(06)00078-0
840
True
16781134
